TREML, Jakub, Veronika LELÁKOVÁ, Karel ŠMEJKAL, T PAULICKOVA, S LABUDA, S GRANICA, J HAVLIK, Dagmar JANKOVSKÁ, Tereza PADRTOVÁ and J HOSEK. Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System. Biomolecules. BASEL: MDPI, 2019, vol. 9, No 9, 16 pp. ISSN 0066-605X. doi:10.3390/biom9090468.
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Basic information
Original name Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System
Authors TREML, Jakub, Veronika LELÁKOVÁ, Karel ŠMEJKAL, T PAULICKOVA, S LABUDA, S GRANICA, J HAVLIK, Dagmar JANKOVSKÁ, Tereza PADRTOVÁ and J HOSEK.
Edition Biomolecules, BASEL, MDPI, 2019, 0066-605X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Pharmacy
Doi http://dx.doi.org/10.3390/biom9090468
UT WoS 000489102800080
Keywords in English stilbenoid; antioxidant; pro-oxidant; pyocyanin; Nrf2; macrophages
Tags International impact, Reviewed
Changed by Changed by: PharmDr. Jitka Michlíčková, učo 151288. Changed: 17/2/2021 13:44.
Abstract
The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have investigated a group of 19 stilbenoid substances in vitro using a cellular model of THP-1 macrophage-like cells and pyocyanin-induced oxidative stress to evaluate their antioxidant or pro-oxidant properties. Then we have determined any effects that they might have on the expression of the enzymes catalase, glutathione peroxidase, and heme oxygenase-1, and their effects on the activation of Nrf2. The experimental results showed that these stilbenoids could affect the formation of reactive oxygen species in a cellular model, producing either an antioxidative or pro-oxidative effect, depending on the structure pinostilbene (2) worked as a pro-oxidant and also decreased expression of catalase in the cell culture. Piceatannol (4) had shown reactive oxygen species (ROS) scavenging activity, whereas isorhapontigenin (18) had a mild direct antioxidant effect and activated Nrf2-antioxidant response element (ARE) system and elevated expression of Nrf2 and catalase. Their effects shown on cells in vitro warrant their further study in vivo.
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