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@article{1726960,
author = {Treml, Jakub and Leláková, Veronika and Šmejkal, Karel and Paulickova, T and Labuda, S and Granica, S and Havlik, J and Jankovská, Dagmar and Padrtová, Tereza and Hosek, J},
article_location = {BASEL},
article_number = {9},
doi = {http://dx.doi.org/10.3390/biom9090468},
keywords = {stilbenoid; antioxidant; pro-oxidant; pyocyanin; Nrf2; macrophages},
language = {eng},
issn = {0066-605X},
journal = {Biomolecules},
title = {Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System},
volume = {9},
year = {2019}
}
TY - JOUR
ID - 1726960
AU - Treml, Jakub - Leláková, Veronika - Šmejkal, Karel - Paulickova, T - Labuda, S - Granica, S - Havlik, J - Jankovská, Dagmar - Padrtová, Tereza - Hosek, J
PY - 2019
TI - Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System
JF - Biomolecules
VL - 9
IS - 9
PB - MDPI
SN - 0066605X
KW - stilbenoid
KW - antioxidant
KW - pro-oxidant
KW - pyocyanin
KW - Nrf2
KW - macrophages
N2 - The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have investigated a group of 19 stilbenoid substances in vitro using a cellular model of THP-1 macrophage-like cells and pyocyanin-induced oxidative stress to evaluate their antioxidant or pro-oxidant properties. Then we have determined any effects that they might have on the expression of the enzymes catalase, glutathione peroxidase, and heme oxygenase-1, and their effects on the activation of Nrf2. The experimental results showed that these stilbenoids could affect the formation of reactive oxygen species in a cellular model, producing either an antioxidative or pro-oxidative effect, depending on the structure pinostilbene (2) worked as a pro-oxidant and also decreased expression of catalase in the cell culture. Piceatannol (4) had shown reactive oxygen species (ROS) scavenging activity, whereas isorhapontigenin (18) had a mild direct antioxidant effect and activated Nrf2-antioxidant response element (ARE) system and elevated expression of Nrf2 and catalase. Their effects shown on cells in vitro warrant their further study in vivo.
ER -
TREML, Jakub, Veronika LELÁKOVÁ, Karel ŠMEJKAL, T PAULICKOVA, S LABUDA, S GRANICA, J HAVLIK, Dagmar JANKOVSKÁ, Tereza PADRTOVÁ and J HOSEK. Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System. \textit{Biomolecules}. BASEL: MDPI, 2019, vol.~9, No~9, 16 pp. ISSN~0066-605X. Available from: https://dx.doi.org/10.3390/biom9090468.
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