| MALANÍK, Milan, Jakub TREML, Veronika LELÁKOVÁ, Daniela NYKODÝMOVÁ, Michal ORAVEC, Jaromír MAREK and Karel ŠMEJKAL. Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera. Bioorganic Chemistry. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020, vol. 104, NOV, p. 104298-104304. ISSN 0045-2068. Available from: https://dx.doi.org/10.1016/j.bioorg.2020.104298. |
Other formats:
BibTeX
LaTeX
RIS
@article{1727696,
author = {Malaník, Milan and Treml, Jakub and Leláková, Veronika and Nykodýmová, Daniela and Oravec, Michal and Marek, Jaromír and Šmejkal, Karel},
article_location = {SAN DIEGO},
article_number = {NOV},
doi = {http://dx.doi.org/10.1016/j.bioorg.2020.104298},
keywords = {Broussonetia papyrifera; Anti-inflammatory; Antioxidant; NF-kappa B},
language = {eng},
issn = {0045-2068},
journal = {Bioorganic Chemistry},
title = {Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera},
url = {https://www.sciencedirect.com/science/article/pii/S0045206820315960?via%3Dihub},
volume = {104},
year = {2020}
}
TY - JOUR
ID - 1727696
AU - Malaník, Milan - Treml, Jakub - Leláková, Veronika - Nykodýmová, Daniela - Oravec, Michal - Marek, Jaromír - Šmejkal, Karel
PY - 2020
TI - Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera
JF - Bioorganic Chemistry
VL - 104
IS - NOV
SP - 104298
EP - 104298
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 00452068
KW - Broussonetia papyrifera
KW - Anti-inflammatory
KW - Antioxidant
KW - NF-kappa B
UR - https://www.sciencedirect.com/science/article/pii/S0045206820315960?via%3Dihub
N2 - Extensive phytochemical analysis of the CHCl3-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1-14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7-10 and 12 showed inhibitory effects on NF-kappa B/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1 beta and TNF-alpha in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.
ER -
MALANÍK, Milan, Jakub TREML, Veronika LELÁKOVÁ, Daniela NYKODÝMOVÁ, Michal ORAVEC, Jaromír MAREK and Karel ŠMEJKAL. Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera. \textit{Bioorganic Chemistry}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020, vol.~104, NOV, p.~104298-104304. ISSN~0045-2068. Available from: https://dx.doi.org/10.1016/j.bioorg.2020.104298.
|
