Anti-inflammatory and antioxidant properties of chemical
constituents of Broussonetia papyrifera

J 2020

Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera

MALANÍK, Milan, Jakub TREML, Veronika LELÁKOVÁ, Daniela NYKODÝMOVÁ, Michal ORAVEC et. al.

Basic information

Original name

Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera

Authors

MALANÍK, Milan (203 Czech Republic, guarantor, belonging to the institution), Jakub TREML (203 Czech Republic, belonging to the institution), Veronika LELÁKOVÁ (703 Slovakia, belonging to the institution), Daniela NYKODÝMOVÁ (203 Czech Republic, belonging to the institution), Michal ORAVEC (203 Czech Republic), Jaromír MAREK (203 Czech Republic, belonging to the institution) and Karel ŠMEJKAL (203 Czech Republic, belonging to the institution)

Edition

Bioorganic Chemistry, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020, 0045-2068

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.275

RIV identification code

RIV/00216224:14160/20:00117745

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.1016/j.bioorg.2020.104298

UT WoS

000592397400007

Keywords in English

Broussonetia papyrifera; Anti-inflammatory; Antioxidant; NF-kappa B

Abstract

V originále

Extensive phytochemical analysis of the CHCl3-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1-14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7-10 and 12 showed inhibitory effects on NF-kappa B/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1 beta and TNF-alpha in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.

Links

90127, large research infrastructures

Name: CIISB II

Citovat

MALANÍK, Milan, Jakub TREML, Veronika LELÁKOVÁ, Daniela NYKODÝMOVÁ, Michal ORAVEC, Jaromír MAREK and Karel ŠMEJKAL. Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera. Bioorganic Chemistry. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020, vol. 104, NOV, p. 104298-104304. ISSN 0045-2068. Available from: https://dx.doi.org/10.1016/j.bioorg.2020.104298.

@article{1727696,
   author = {Malaník, Milan and Treml, Jakub and Leláková, Veronika and Nykodýmová, Daniela and Oravec, Michal and Marek, Jaromír and Šmejkal, Karel},
   article_location = {SAN DIEGO},
   article_number = {NOV},
   doi = {http://dx.doi.org/10.1016/j.bioorg.2020.104298},
   keywords = {Broussonetia papyrifera; Anti-inflammatory; Antioxidant; NF-kappa B},
   language = {eng},
   issn = {0045-2068},
   journal = {Bioorganic Chemistry},
   title = {Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera},
   url = {https://www.sciencedirect.com/science/article/pii/S0045206820315960?via%3Dihub},
   volume = {104},
   year = {2020}
}

TY  - JOUR
ID  - 1727696
AU  - Malaník, Milan - Treml, Jakub - Leláková, Veronika - Nykodýmová, Daniela - Oravec, Michal - Marek, Jaromír - Šmejkal, Karel
PY  - 2020
TI  - Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera
JF  - Bioorganic Chemistry
VL  - 104
IS  - NOV
SP  - 104298
EP  - 104298
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 00452068
KW  - Broussonetia papyrifera
KW  - Anti-inflammatory
KW  - Antioxidant
KW  - NF-kappa B
UR  - https://www.sciencedirect.com/science/article/pii/S0045206820315960?via%3Dihub
N2  - Extensive phytochemical analysis of the CHCl3-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1-14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7-10 and 12 showed inhibitory effects on NF-kappa B/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1 beta and TNF-alpha in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.
ER  -

MALANÍK, Milan, Jakub TREML, Veronika LELÁKOVÁ, Daniela NYKODÝMOVÁ, Michal ORAVEC, Jaromír MAREK and Karel ŠMEJKAL. Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera. \textit{Bioorganic Chemistry}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020, vol.~104, NOV, p.~104298-104304. ISSN~0045-2068. Available from: https://dx.doi.org/10.1016/j.bioorg.2020.104298.

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