Differential diagnosis of tremor syndromes using MRI
relaxometry

J 2020

Differential diagnosis of tremor syndromes using MRI relaxometry

FILIP, Pavel, Lubomír VOJTÍŠEK, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI et. al.

Basic information

Original name

Differential diagnosis of tremor syndromes using MRI relaxometry

Authors

FILIP, Pavel (703 Slovakia, guarantor, belonging to the institution), Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), Marek BALÁŽ (703 Slovakia, belonging to the institution), Silvia MANGIA, Shalom MICHAELI, Rastislav ŠUMEC (703 Slovakia, belonging to the institution) and Martin BAREŠ (203 Czech Republic, belonging to the institution)

Edition

Parkinsonism and Related Disorders, Oxford, Elsevier, 2020, 1353-8020

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.891

RIV identification code

RIV/00216224:14110/20:00117873

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.parkreldis.2020.10.048

UT WoS

000603608900011

Keywords in English

Tremor; Parkinson's disease; Essential tremor; Adiabatic T1 rho and T2 rho mapping; T1 and T2 mapping

Abstract

V originále

Differential diagnosis of the most common tremor syndromes - essential tremor (ET) and Parkinson's disease (PD) is burdened with high error rate. However, diagnostic MRI biomarkers applicable in this clinically highly relevant scenario remain an unfulfilled objective. The presented study was designed in search for possible candidate MRI protocols relevant for differential diagnostic process in tremor syndromes.10 non-advanced tremor-dominant PD patients meeting diagnostic criteria for clinically established PD, 12 isolated ET patients and 16 healthy controls were enrolled into this study. The study focused on relaxation MRI protocols - T1, T2, adiabatic T1 rho and adiabatic T2 rho due to their relatively low post-processing requirements enabling implementation into routine clinical practice. Compared to ET, PD patients had significantly longer T2 relaxation times in striata with dominant findings in the putamen contralateral to the clinically more affected body side. This difference was driven by alterations in the PD group as confirmed in the complementary comparison with healthy controls. According to the receiver operating characteristic analysis, this region provided a reasonable sensitivity of 0.91 and specificity of 0.89 in the differential diagnosis of PD and ET. In PD patients, we further found prolonged T1 rho in the substantia nigra compared to ET and healthy controls, and shorter T2 and T2 rho in the cerebellum compared to healthy controls. T2 relaxation time in the putamen contralateral to the clinically more affected body side is a plausible candidate diagnostic marker for the differentiation of PD and ET.

Links

691110, interní kód MU

Name: Advanced MR methods for characterization of microstructural brain damage (MICROBRADAM) (Acronym: MICROBRADAM)

Investor: European Union, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

FILIP, Pavel, Lubomír VOJTÍŠEK, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Rastislav ŠUMEC and Martin BAREŠ. Differential diagnosis of tremor syndromes using MRI relaxometry. Parkinsonism and Related Disorders. Oxford: Elsevier, 2020, vol. 81, December 2020, p. 190-193. ISSN 1353-8020. Available from: https://dx.doi.org/10.1016/j.parkreldis.2020.10.048.

@article{1730416,
   author = {Filip, Pavel and Vojtíšek, Lubomír and Baláž, Marek and Mangia, Silvia and Michaeli, Shalom and Šumec, Rastislav and Bareš, Martin},
   article_location = {Oxford},
   article_number = {December 2020},
   doi = {http://dx.doi.org/10.1016/j.parkreldis.2020.10.048},
   keywords = {Tremor; Parkinson's disease; Essential tremor; Adiabatic T1 rho and T2 rho mapping; T1 and T2 mapping},
   language = {eng},
   issn = {1353-8020},
   journal = {Parkinsonism and Related Disorders},
   title = {Differential diagnosis of tremor syndromes using MRI relaxometry},
   url = {https://www.sciencedirect.com/science/article/pii/S135380202030849X},
   volume = {81},
   year = {2020}
}

TY  - JOUR
ID  - 1730416
AU  - Filip, Pavel - Vojtíšek, Lubomír - Baláž, Marek - Mangia, Silvia - Michaeli, Shalom - Šumec, Rastislav - Bareš, Martin
PY  - 2020
TI  - Differential diagnosis of tremor syndromes using MRI relaxometry
JF  - Parkinsonism and Related Disorders
VL  - 81
IS  - December 2020
SP  - 190-193
EP  - 190-193
PB  - Elsevier
SN  - 13538020
KW  - Tremor
KW  - Parkinson's disease
KW  - Essential tremor
KW  - Adiabatic T1 rho and T2 rho mapping
KW  - T1 and T2 mapping
UR  - https://www.sciencedirect.com/science/article/pii/S135380202030849X
L2  - https://www.sciencedirect.com/science/article/pii/S135380202030849X
N2  - Differential diagnosis of the most common tremor syndromes - essential tremor (ET) and Parkinson's disease (PD) is burdened with high error rate. However, diagnostic MRI biomarkers applicable in this clinically highly relevant scenario remain an unfulfilled objective. The presented study was designed in search for possible candidate MRI protocols relevant for differential diagnostic process in tremor syndromes.10 non-advanced tremor-dominant PD patients meeting diagnostic criteria for clinically established PD, 12 isolated ET patients and 16 healthy controls were enrolled into this study. The study focused on relaxation MRI protocols - T1, T2, adiabatic T1 rho and adiabatic T2 rho due to their relatively low post-processing requirements enabling implementation into routine clinical practice. Compared to ET, PD patients had significantly longer T2 relaxation times in striata with dominant findings in the putamen contralateral to the clinically more affected body side. This difference was driven by alterations in the PD group as confirmed in the complementary comparison with healthy controls. According to the receiver operating characteristic analysis, this region provided a reasonable sensitivity of 0.91 and specificity of 0.89 in the differential diagnosis of PD and ET. In PD patients, we further found prolonged T1 rho in the substantia nigra compared to ET and healthy controls, and shorter T2 and T2 rho in the cerebellum compared to healthy controls. T2 relaxation time in the putamen contralateral to the clinically more affected body side is a plausible candidate diagnostic marker for the differentiation of PD and ET.
ER  -

FILIP, Pavel, Lubomír VOJTÍŠEK, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Rastislav ŠUMEC and Martin BAREŠ. Differential diagnosis of tremor syndromes using MRI relaxometry. \textit{Parkinsonism and Related Disorders}. Oxford: Elsevier, 2020, vol.~81, December 2020, p.~190-193. ISSN~1353-8020. Available from: https://dx.doi.org/10.1016/j.parkreldis.2020.10.048.

Detailed Information on Publication Record