J 2020

Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis

IURCA, I., A. TIRPE, A. A. ZIMTA, C. MOLDOVAN, D. GULEI et. al.

Basic information

Original name

Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis

Authors

IURCA, I. (642 Romania), A. TIRPE (642 Romania), A. A. ZIMTA (642 Romania), C. MOLDOVAN (642 Romania), D. GULEI (642 Romania), Ondřej SLABÝ (203 Czech Republic, belonging to the institution), G. CONDORELLI (380 Italy) and I. BERINDAN-NEAGOE (642 Romania, guarantor)

Edition

Frontiers in Immunology, LAUSANNE, FRONTIERS MEDIA SA, 2020, 1664-3224

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 7.561

RIV identification code

RIV/00216224:14110/20:00117883

Organization unit

Faculty of Medicine

DOI

UT WoS

000537072800001

Keywords in English

macrophage; cancer; metastasis; microRNA; invasion

Tags

Tags

International impact, Reviewed
Změněno: 17/3/2021 13:14, Mgr. Tereza Miškechová

Abstract

V originále

Advancement in cancer research has shown that the tumor microenvironment plays a crucial role in the installation, progression, and dissemination of cancer cells. Among the heterogeneous panel of cells within the malignant microenvironment are tumor-associated macrophages that are sustaining the malignant cells through strict feedback mechanisms and spatial distribution. Considering that the presence of metastasis is one of the main feature associated with decreased survival rates among patients, in the present article we briefly present the involvement of tumor-associated macrophages in the hallmarks of metastasis and their microRNA-related regulation with a focus on lung cancer in order to coordinate the vast information under one pathology. As shown, these cells have emerged as coordinators of immunosuppression, angiogenesis and lymphangiogenesis, vessel intravasation and extravasation of cancer cells, and premetastatic niche formation, transforming the macrophages in potential therapeutic targets and also prognostic markers according to their density within the tumor and polarization phenotype. An indirect therapeutic approach on tumor-associated macrophages can be also represented by regulation of microRNAs involved in their polarization and implicit oncogenic features. Examples of these microRNAs consist in the highly studied miR-21 and miR-155, but also other microRNA with less feedback in the literature: miR-1207-5p, miR-193b, miR-320a, and others.