Incidence trends of esophageal cancer in the Czech Republic by
histological subtype and stage and prescription rate of acid
suppressing drugs

J 2020

Incidence trends of esophageal cancer in the Czech Republic by histological subtype and stage and prescription rate of acid suppressing drugs

KROUPA, Radek, Ivana KATINOVÁ, Tomáš PAVLÍK, Lumír KUNOVSKÝ, Vladimír PROCHÁZKA et. al.

Basic information

Original name

Incidence trends of esophageal cancer in the Czech Republic by histological subtype and stage and prescription rate of acid suppressing drugs

Authors

KROUPA, Radek (203 Czech Republic, guarantor, belonging to the institution), Ivana KATINOVÁ (203 Czech Republic, belonging to the institution), Tomáš PAVLÍK (203 Czech Republic, belonging to the institution), Lumír KUNOVSKÝ (203 Czech Republic, belonging to the institution), Vladimír PROCHÁZKA (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Barbora PACKOVÁ (203 Czech Republic, belonging to the institution), Zdeněk KALA (203 Czech Republic, belonging to the institution) and Jiří DOLINA (203 Czech Republic, belonging to the institution)

Edition

Cancer epidemiology, Oxford, Elsevier, 2020, 1877-7821

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.984

RIV identification code

RIV/00216224:14110/20:00120084

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.canep.2020.101853

UT WoS

000596559500014

Keywords in English

Esophageal cancer; Esophageal adenocarcinoma; Squamous cell carcinoma; Proton pump inhibitor; Gastroesophageal reflux disease

Abstract

V originále

Background: Incidence of esophageal adenocarcinoma (EAC) associated with gastroesophageal reflux disease has increased substantially in developed countries during the past decades. We aimed to analyze trends in incidence of esophageal cancer (EC) by histological subtypes and trends in acid suppressing drugs prescription in the Czech Republic. Methods: The incidence of EC by histological subtypes, sex, and stage from 1984-2017 was examined using data from the Czech National Cancer Registry. Defined daily doses of acid inhibiting drugs were analyzed from annual reports by the State Institute for Drug Control. Results: Age standardized incidence of EAC in men increased annually by 4.88 % with 95 % confidence interval (CI) (4.32, 5.45) from 1984 to 2017, and by 5.11 % (95 % CI, 4.02, 6.20) in women. Squamous cell carcinoma increased annually by 5.52 % (95 % CI, 2.49, 8.64) from 1984 to 1994 with subsequent slower increase by 0.87 % (95 % CI, 0.25, 1.50) from 1994 to 2017. It still represents 50 % of all EC in 2017. The comparable early stages of EAC showed similar annual percentage change of 5.77 %. From 2001 to 2018 the use of proton pump inhibitors increased dramatically from 6.8 to 72.9 defined daily doses per 1000 inhabitants. Conclusion: The incidence of EAC is still increasing in the Czech Republic, however it represents less than half of ECs. The incidence of squamous cell carcinoma is relatively stable. Broad use of acid suppressing drugs did not seem to impact the incidence of EAC even in early stages.

Links

NU20-03-00126, research and development project

Name: Hostitelský mikrobiom ve vztahu k rozvoji Barrettova jícnu a adenokarcinomu jícnu

Investor: Ministry of Health of the CR, Host microbiome in relation to Barrett ́s esophagus and esophageal adenocarcinoma development, Subprogram 1 - standard

Citovat

KROUPA, Radek, Ivana KATINOVÁ, Tomáš PAVLÍK, Lumír KUNOVSKÝ, Vladimír PROCHÁZKA, Petra BOŘILOVÁ LINHARTOVÁ, Barbora PACKOVÁ, Zdeněk KALA and Jiří DOLINA. Incidence trends of esophageal cancer in the Czech Republic by histological subtype and stage and prescription rate of acid suppressing drugs. Cancer epidemiology. Oxford: Elsevier, 2020, vol. 69, DEC 2020, p. 1-7. ISSN 1877-7821. Available from: https://dx.doi.org/10.1016/j.canep.2020.101853.

@article{1730595,
   author = {Kroupa, Radek and Katinová, Ivana and Pavlík, Tomáš and Kunovský, Lumír and Procházka, Vladimír and Bořilová Linhartová, Petra and Packová, Barbora and Kala, Zdeněk and Dolina, Jiří},
   article_location = {Oxford},
   article_number = {DEC 2020},
   doi = {http://dx.doi.org/10.1016/j.canep.2020.101853},
   keywords = {Esophageal cancer; Esophageal adenocarcinoma; Squamous cell carcinoma; Proton pump inhibitor; Gastroesophageal reflux disease},
   language = {eng},
   issn = {1877-7821},
   journal = {Cancer epidemiology},
   title = {Incidence trends of esophageal cancer in the Czech Republic by histological subtype and stage and prescription rate of acid suppressing drugs},
   url = {https://www.sciencedirect.com/science/article/pii/S1877782120301879?via%3Dihub},
   volume = {69},
   year = {2020}
}

TY  - JOUR
ID  - 1730595
AU  - Kroupa, Radek - Katinová, Ivana - Pavlík, Tomáš - Kunovský, Lumír - Procházka, Vladimír - Bořilová Linhartová, Petra - Packová, Barbora - Kala, Zdeněk - Dolina, Jiří
PY  - 2020
TI  - Incidence trends of esophageal cancer in the Czech Republic by histological subtype and stage and prescription rate of acid suppressing drugs
JF  - Cancer epidemiology
VL  - 69
IS  - DEC 2020
SP  - 1-7
EP  - 1-7
PB  - Elsevier
SN  - 18777821
KW  - Esophageal cancer
KW  - Esophageal adenocarcinoma
KW  - Squamous cell carcinoma
KW  - Proton pump inhibitor
KW  - Gastroesophageal reflux disease
UR  - https://www.sciencedirect.com/science/article/pii/S1877782120301879?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S1877782120301879?via%3Dihub
N2  - Background: Incidence of esophageal adenocarcinoma (EAC) associated with gastroesophageal reflux disease has increased substantially in developed countries during the past decades. We aimed to analyze trends in incidence of esophageal cancer (EC) by histological subtypes and trends in acid suppressing drugs prescription in the Czech Republic. Methods: The incidence of EC by histological subtypes, sex, and stage from 1984-2017 was examined using data from the Czech National Cancer Registry. Defined daily doses of acid inhibiting drugs were analyzed from annual reports by the State Institute for Drug Control. Results: Age standardized incidence of EAC in men increased annually by 4.88 % with 95 % confidence interval (CI) (4.32, 5.45) from 1984 to 2017, and by 5.11 % (95 % CI, 4.02, 6.20) in women. Squamous cell carcinoma increased annually by 5.52 % (95 % CI, 2.49, 8.64) from 1984 to 1994 with subsequent slower increase by 0.87 % (95 % CI, 0.25, 1.50) from 1994 to 2017. It still represents 50 % of all EC in 2017. The comparable early stages of EAC showed similar annual percentage change of 5.77 %. From 2001 to 2018 the use of proton pump inhibitors increased dramatically from 6.8 to 72.9 defined daily doses per 1000 inhabitants. Conclusion: The incidence of EAC is still increasing in the Czech Republic, however it represents less than half of ECs. The incidence of squamous cell carcinoma is relatively stable. Broad use of acid suppressing drugs did not seem to impact the incidence of EAC even in early stages.
ER  -

KROUPA, Radek, Ivana KATINOVÁ, Tomáš PAVLÍK, Lumír KUNOVSKÝ, Vladimír PROCHÁZKA, Petra BOŘILOVÁ LINHARTOVÁ, Barbora PACKOVÁ, Zdeněk KALA and Jiří DOLINA. Incidence trends of esophageal cancer in the Czech Republic by histological subtype and stage and prescription rate of acid suppressing drugs. \textit{Cancer epidemiology}. Oxford: Elsevier, 2020, vol.~69, DEC 2020, p.~1-7. ISSN~1877-7821. Available from: https://dx.doi.org/10.1016/j.canep.2020.101853.

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