Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond

J 2021

Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond

KEJÍK, Zdenek, Robert KAPLÁNEK, Michal MASAŘÍK, Petr BABULA, Adam MATKOWSKI et. al.

Basic information

Original name

Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond

Authors

KEJÍK, Zdenek (203 Czech Republic), Robert KAPLÁNEK (203 Czech Republic), Michal MASAŘÍK (203 Czech Republic, belonging to the institution), Petr BABULA (203 Czech Republic, belonging to the institution), Adam MATKOWSKI (616 Poland), Petr FILIPENSKÝ (203 Czech Republic), Katerina VESELÁ (203 Czech Republic), Jakub GBUREK (203 Czech Republic), David SÝKORA (203 Czech Republic), Pavel MARTÁSEK (203 Czech Republic) and Milan JAKUBEK (203 Czech Republic, guarantor)

Edition

International Journal of Molecular Sciences, Basel, MDPI, 2021, 1422-0067

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.208

RIV identification code

RIV/00216224:14110/21:00119787

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/ijms22020646

UT WoS

000611297300001

Keywords in English

flavonoids; iron ions; metallocomplexes

Abstract

V originále

Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron. In this review, we explain the interaction of various flavonoid structures with Fe(II) and Fe(III) ions and critically discuss the influence of chelated ions on the flavonoid biochemical properties. In addition, specific biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been included in this review.

Links

MUNI/A/1307/2019, interní kód MU

Name: Kardiovaskulární systém od A do Z (Acronym: KAVASAZ)

Investor: Masaryk University, Category A

MUNI/A/1453/2019, interní kód MU

Name: Příspěvek ke studiu molekulární, buněčné, tkáňové a systémové patofyziologie vybraných komplexních nemocí

Investor: Masaryk University, Category A

TN01000013, research and development project

Name: Personalizovaná medicína - diagnostika a terapie

Investor: Technology Agency of the Czech Republic, Personalized Medicine – Diagnostics and Therapy

Citovat

KEJÍK, Zdenek, Robert KAPLÁNEK, Michal MASAŘÍK, Petr BABULA, Adam MATKOWSKI, Petr FILIPENSKÝ, Katerina VESELÁ, Jakub GBUREK, David SÝKORA, Pavel MARTÁSEK and Milan JAKUBEK. Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond. International Journal of Molecular Sciences. Basel: MDPI, 2021, vol. 22, No 2, p. 1-20. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms22020646.

@article{1732813,
   author = {Kejík, Zdenek and Kaplánek, Robert and Masařík, Michal and Babula, Petr and Matkowski, Adam and Filipenský, Petr and Veselá, Katerina and Gburek, Jakub and Sýkora, David and Martásek, Pavel and Jakubek, Milan},
   article_location = {Basel},
   article_number = {2},
   doi = {http://dx.doi.org/10.3390/ijms22020646},
   keywords = {flavonoids; iron ions; metallocomplexes},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond},
   url = {https://www.mdpi.com/1422-0067/22/2/646},
   volume = {22},
   year = {2021}
}

TY  - JOUR
ID  - 1732813
AU  - Kejík, Zdenek - Kaplánek, Robert - Masařík, Michal - Babula, Petr - Matkowski, Adam - Filipenský, Petr - Veselá, Katerina - Gburek, Jakub - Sýkora, David - Martásek, Pavel - Jakubek, Milan
PY  - 2021
TI  - Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond
JF  - International Journal of Molecular Sciences
VL  - 22
IS  - 2
SP  - 1-20
EP  - 1-20
PB  - MDPI
SN  - 14220067
KW  - flavonoids
KW  - iron ions
KW  - metallocomplexes
UR  - https://www.mdpi.com/1422-0067/22/2/646
N2  - Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron. In this review, we explain the interaction of various flavonoid structures with Fe(II) and Fe(III) ions and critically discuss the influence of chelated ions on the flavonoid biochemical properties. In addition, specific biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been included in this review.
ER  -

KEJÍK, Zdenek, Robert KAPLÁNEK, Michal MASAŘÍK, Petr BABULA, Adam MATKOWSKI, Petr FILIPENSKÝ, Katerina VESELÁ, Jakub GBUREK, David SÝKORA, Pavel MARTÁSEK and Milan JAKUBEK. Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond. \textit{International Journal of Molecular Sciences}. Basel: MDPI, 2021, vol.~22, No~2, p.~1-20. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms22020646.

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