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@article{1732813,
author = {Kejík, Zdenek and Kaplánek, Robert and Masařík, Michal and Babula, Petr and Matkowski, Adam and Filipenský, Petr and Veselá, Katerina and Gburek, Jakub and Sýkora, David and Martásek, Pavel and Jakubek, Milan},
article_location = {Basel},
article_number = {2},
doi = {http://dx.doi.org/10.3390/ijms22020646},
keywords = {flavonoids; iron ions; metallocomplexes},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond},
url = {https://www.mdpi.com/1422-0067/22/2/646},
volume = {22},
year = {2021}
}
TY - JOUR
ID - 1732813
AU - Kejík, Zdenek - Kaplánek, Robert - Masařík, Michal - Babula, Petr - Matkowski, Adam - Filipenský, Petr - Veselá, Katerina - Gburek, Jakub - Sýkora, David - Martásek, Pavel - Jakubek, Milan
PY - 2021
TI - Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond
JF - International Journal of Molecular Sciences
VL - 22
IS - 2
SP - 1-20
EP - 1-20
PB - MDPI
SN - 14220067
KW - flavonoids
KW - iron ions
KW - metallocomplexes
UR - https://www.mdpi.com/1422-0067/22/2/646
N2 - Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron. In this review, we explain the interaction of various flavonoid structures with Fe(II) and Fe(III) ions and critically discuss the influence of chelated ions on the flavonoid biochemical properties. In addition, specific biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been included in this review.
ER -
KEJÍK, Zdenek, Robert KAPLÁNEK, Michal MASAŘÍK, Petr BABULA, Adam MATKOWSKI, Petr FILIPENSKÝ, Katerina VESELÁ, Jakub GBUREK, David SÝKORA, Pavel MARTÁSEK and Milan JAKUBEK. Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond. \textit{International Journal of Molecular Sciences}. Basel: MDPI, 2021, vol.~22, No~2, p.~1-20. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms22020646.
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