VACLAVIK, J., P. SEHONOVA, N. HODKOVICOVA, L. VECERKOVA, J. BLAHOVA, Aleš FRANC, P. MARSALEK, J. MARES, F. TICHY, Z. SVOBODOVA and C. FAGGIO. The effect of foodborne sertraline on rainbow trout (Oncorhynchus mykiss). Science of the Total Environment. Amsterdam: Elsevier Science, 2020, vol. 708, No 135082, p. 1-7. ISSN 0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2019.135082. |
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@article{1733357, author = {Vaclavik, J. and Sehonova, P. and Hodkovicova, N. and Vecerkova, L. and Blahova, J. and Franc, Aleš and Marsalek, P. and Mares, J. and Tichy, F. and Svobodova, Z. and Faggio, C.}, article_location = {Amsterdam}, article_number = {135082}, doi = {http://dx.doi.org/10.1016/j.scitotenv.2019.135082}, keywords = {Antidepressant; Fish; Behaviour; Haematological profile; Oxidative stress}, language = {eng}, issn = {0048-9697}, journal = {Science of the Total Environment}, title = {The effect of foodborne sertraline on rainbow trout (Oncorhynchus mykiss)}, url = {http://www.sciencedirect.com/science/article/pii/S0048969719350740}, volume = {708}, year = {2020} }
TY - JOUR ID - 1733357 AU - Vaclavik, J. - Sehonova, P. - Hodkovicova, N. - Vecerkova, L. - Blahova, J. - Franc, Aleš - Marsalek, P. - Mares, J. - Tichy, F. - Svobodova, Z. - Faggio, C. PY - 2020 TI - The effect of foodborne sertraline on rainbow trout (Oncorhynchus mykiss) JF - Science of the Total Environment VL - 708 IS - 135082 SP - 1-7 EP - 1-7 PB - Elsevier Science SN - 00489697 KW - Antidepressant KW - Fish KW - Behaviour KW - Haematological profile KW - Oxidative stress UR - http://www.sciencedirect.com/science/article/pii/S0048969719350740 L2 - http://www.sciencedirect.com/science/article/pii/S0048969719350740 N2 - The worldwide consumption of antidepressants is raising as well as their concentrations in the aquatic environment. This increases the risk of food chain contamination and bioaccumulation in aquatic biota. The aim of this study was to describe a potential risk of sertraline as a pollutant from water environment, wherein rainbow trout (Oncorhynchus mykiss) has been chosen as the test organism, because predatory fish are on the top of the food chain in the aquatic environment. The effects of foodborne sertraline were tested on rainbow trout during a 28-day toxicity test according to OECD 215 method. Sertraline was incorporated in commercial feed at a dose of 4.4 mu g/kg (environmental concentration), 42 mu g/kg and 400 mu g/kg. The results confirmed that sertraline has a significant effect on fish behaviour, resulting in suppression of the escape reflex and increased resistance to stress. Moreover, increased Fultons condition factor was found in fish fed with the highest concentration of sertraline. Haematological analysis revealed a statistically significant increase in the number of neutrophilic bands and neutrophil/lymphocyte ratio, and decreased number of lymphocytes. The results of biochemical examination showed a statistically significant decrease in ammonia and lactate concentrations and histological examination revealed changes in gills and caudal kidney. Although sertraline reduces stress in fish, the decline in nonspecific immunity is a risk to fish population stability. (C) 2019 Elsevier B.V. All rights reserved. ER -
VACLAVIK, J., P. SEHONOVA, N. HODKOVICOVA, L. VECERKOVA, J. BLAHOVA, Aleš FRANC, P. MARSALEK, J. MARES, F. TICHY, Z. SVOBODOVA and C. FAGGIO. The effect of foodborne sertraline on rainbow trout (Oncorhynchus mykiss). \textit{Science of the Total Environment}. Amsterdam: Elsevier Science, 2020, vol.~708, No~135082, p.~1-7. ISSN~0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2019.135082.
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