J 2020

Acupuncture in the treatment of acute toxicity during and after head and neck cancer radiotherapy: Interim analysis of randomized prospective open-label trial

DYMÁČKOVÁ, Radana, Tomáš KAZDA, Marek SLÁVIK, Iveta SELINGEROVA, Pavel ŠLAMPA et. al.

Basic information

Original name

Acupuncture in the treatment of acute toxicity during and after head and neck cancer radiotherapy: Interim analysis of randomized prospective open-label trial

Authors

DYMÁČKOVÁ, Radana (203 Czech Republic, belonging to the institution), Tomáš KAZDA (203 Czech Republic, guarantor, belonging to the institution), Marek SLÁVIK (703 Slovakia, belonging to the institution), Iveta SELINGEROVA (203 Czech Republic), Pavel ŠLAMPA (203 Czech Republic, belonging to the institution) and Ondřej SLÁMA (203 Czech Republic, belonging to the institution)

Edition

Biomedical Papers, Olomouc, Palacky University, 2020, 1213-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.245

RIV identification code

RIV/00216224:14110/20:00118033

Organization unit

Faculty of Medicine

DOI

UT WoS

000604951200014

Keywords in English

acupuncture; head and neck; cancer; radiotherapy; toxicity

Tags

Tags

International impact, Reviewed
Změněno: 27/1/2021 10:32, Mgr. Tereza Miškechová

Abstract

V originále

Aims. The aim of this investigator-initiated prospective randomized open-label single institutional trial is to evaluate the role of acupuncture in the treatment of acute skin and mucosal toxicity, xerostomia, and perception of taste, pain, and nausea related to curative and adjuvant (chemo)radiotherapy of head and neck cancer. This paper reports pilot data of the first 30 enrolled patients. Methods. Patients were randomized to undergo standard of care radiotherapy +/- chemotherapy and support care defined by our institutional standard operating procedures alone or in the combination with acupuncture which was initiated with the first signs of any toxicity. Results. Fifteen patients were enrolled in both arms and all finished the treatment as planned.The median pain was significantly lower in the acupuncture arm (median 1.6 points vs. 2.5 points on a 10-item Likert scale; P=0.035) as well as duration of acute pain (median 31 days vs. 54 days; P=0.031). Patients with acupuncture had significantly shorter duration of acute skin (median 44 days vs. 109 days; P<0.001) and mucosal toxicity (median 34 days vs. 109 days; P<0.001) with no difference in grading of toxicity (median grade 1.6 vs. 1.5; P=0.701 and median grade 1.4 vs. 1.6; P=0.204 for skin and mucosa, respectively). No significant difference was found for other toxicity domains, with the exception of salivation toxicity which was significantly lower in acupuncture arm (median grade 1.3 vs. 1.7; P=0.048). Conclusion. In this interim analysis, acupuncture leads to lower pain andfaster disappearance of skin and mucosal toxicity after (chemo)radiotherapy of head and neck cancer. Description and validation of acupuncture using scientific approaches will further enhance acceptance of this method by both patients and health care providers.