Mechanisms and incidence of torsades de pointes tachycardia

C 2020

Mechanisms and incidence of torsades de pointes tachycardia

NOVOTNÝ, Tomáš

Basic information

Original name

Mechanisms and incidence of torsades de pointes tachycardia

Authors

NOVOTNÝ, Tomáš (203 Czech Republic, guarantor, belonging to the institution)

Edition

1st edition. Neuveden, Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women, p. 303-308, 6 pp. 2020

Publisher

Academic Press

Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

References:

URL

RIV identification code

RIV/00216224:14110/20:00118093

Organization unit

Faculty of Medicine

ISBN

978-0-12-817728-0

DOI

http://dx.doi.org/10.1016/B978-0-12-817728-0.00026-7

Keywords in English

Afterdepolarization; Polymorphic ventricular tachycardia; Re-entry; Sex differences; Torsades de pointes

Abstract

V originále

Torsades de pointes (TdP) is a specific polymorphic ventricular tachycardia related to specific condition – QT interval prolongation in majority of cases. Mechanisms of TdP initiation and perpetuation are still not fully understood and are discussed in detail in this article. TdP is initiated by early afterdepolarizations (EADs). The L-type Ca current (ICa,L) and the Na–Ca exchange current (INCX) are the major currents with potential to create EADs. Density and activity of these currents are influenced by sex hormones which may thus contribute to sex differences in the susceptibility to triggered activity. Female sex was confirmed as an independent risk factor for TdP. In patients with acquired atrioventricular block females developed TdP at QT intervals shorter than males. Thus, there must be other sex specific factors that increase the risk of arrhythmias. In other words, the effect of sex goes beyond the action potential duration. The incidence of TdP is difficult to estimate due to differences in the methodology of a particular study. Nevetheless, it is clearly higher in women.

Citovat

NOVOTNÝ, Tomáš. Mechanisms and incidence of torsades de pointes tachycardia. In Marek Malík. Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women. 1st edition. Neuveden: Academic Press, 2020, p. 303-308. ISBN 978-0-12-817728-0. Available from: https://dx.doi.org/10.1016/B978-0-12-817728-0.00026-7.

@inbook{1737280,
   author = {Novotný, Tomáš},
   address = {Neuveden},
   booktitle = {Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women},
   doi = {http://dx.doi.org/10.1016/B978-0-12-817728-0.00026-7},
   edition = {1st edition},
   editor = {Marek Malík},
   keywords = {Afterdepolarization; Polymorphic ventricular tachycardia; Re-entry; Sex differences; Torsades de pointes},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Neuveden},
   isbn = {978-0-12-817728-0},
   pages = {303-308},
   publisher = {Academic Press},
   title = {Mechanisms and incidence of torsades de pointes tachycardia},
   url = {https://www.sciencedirect.com/science/article/pii/B9780128177280000267},
   year = {2020}
}

TY  - CHAP
ID  - 1737280
AU  - Novotný, Tomáš
PY  - 2020
TI  - Mechanisms and incidence of torsades de pointes tachycardia
VL  - Neuveden
PB  - Academic Press
CY  - Neuveden
SN  - 9780128177280
KW  - Afterdepolarization
KW  - Polymorphic ventricular tachycardia
KW  - Re-entry
KW  - Sex differences
KW  - Torsades de pointes
UR  - https://www.sciencedirect.com/science/article/pii/B9780128177280000267
L2  - https://www.sciencedirect.com/science/article/pii/B9780128177280000267
N2  - Torsades de pointes (TdP) is a specific polymorphic ventricular tachycardia related to specific condition – QT interval prolongation in majority of cases. Mechanisms of TdP initiation and perpetuation are still not fully understood and are discussed in detail in this article. TdP is initiated by early afterdepolarizations (EADs). The L-type Ca current (ICa,L) and the Na–Ca exchange current (INCX) are the major currents with potential to create EADs. Density and activity of these currents are influenced by sex hormones which may thus contribute to sex differences in the susceptibility to triggered activity. Female sex was confirmed as an independent risk factor for TdP. In patients with acquired atrioventricular block females developed TdP at QT intervals shorter than males. Thus, there must be other sex specific factors that increase the risk of arrhythmias. In other words, the effect of sex goes beyond the action potential duration. The incidence of TdP is difficult to estimate due to differences in the methodology of a particular study. Nevetheless, it is clearly higher in women.
ER  -

NOVOTNÝ, Tomáš. Mechanisms and incidence of torsades de pointes tachycardia. In Marek Malík. \textit{Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women}. 1st edition. Neuveden: Academic Press, 2020, p.~303-308. ISBN~978-0-12-817728-0. Available from: https://dx.doi.org/10.1016/B978-0-12-817728-0.00026-7.

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