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@article{1737296,
author = {Krajickova, Dagmar and Král, Jiří and Herzig, Roman and Klzo, L'udovit and Krajina, Antonin and Havelka, Jaroslav and Simunek, Libor and Vysata, Oldrich and Quang, Tran Van and Bar, Michal and Valis, Martin},
article_location = {USA},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-020-78434-8},
keywords = {cerebral venous sinus thrombosis},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis},
url = {https://www.nature.com/articles/s41598-020-78434-8.pdf},
volume = {10},
year = {2020}
}
TY - JOUR
ID - 1737296
AU - Krajickova, Dagmar - Král, Jiří - Herzig, Roman - Klzo, L'udovit - Krajina, Antonin - Havelka, Jaroslav - Simunek, Libor - Vysata, Oldrich - Quang, Tran Van - Bar, Michal - Valis, Martin
PY - 2020
TI - Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis
JF - Scientific Reports
VL - 10
IS - 1
SP - 1-8
EP - 1-8
PB - NATURE RESEARCH
SN - 20452322
KW - cerebral venous sinus thrombosis
UR - https://www.nature.com/articles/s41598-020-78434-8.pdf
L2 - https://www.nature.com/articles/s41598-020-78434-8.pdf
N2 - We aimed was to assess the factors influencing therapy choice and clinical outcome after 3-4 months in patients with cerebral venous sinus thrombosis (CVST). In a retrospective, bi-centric study, the set consisted of 82 consecutive CVST patients (61 females; mean age 33.5 +/- 15.7 years). Following data were collected: baseline characteristics, presence of gender-specific risk factors (GSRF), location and extent of venous sinus impairment, clinical presentation, type of treatment, recanalization, presence of parenchymal lesions, and clinical outcome after 3-4 months (assessed using the modified Rankin Scale [mRS], with excellent outcome defined as mRS 0-1). Multivariate logistic regression analysis was used for statistical evaluation. After 3-4 months, complete recovery was achieved in 41 (50%) and excellent clinical outcome in 67 (81.7%) patients. Female sex (OR 0.11; p=0.0189) and presence of focal neurologic deficit (OR 0.16; p=0.0165) were identified as significant independent negative predictors and, the presence of GSRF (OR 15.63; p=0.0011) as significant independent positive predictor of excellent clinical outcome. In conclusion, in our CVST patients, the presence of GSRF was associated with excellent clinical outcome, while the female sex itself was associated with poorer clinical outcome.
ER -
KRAJICKOVA, Dagmar, Jiří KRÁL, Roman HERZIG, L'udovit KLZO, Antonin KRAJINA, Jaroslav HAVELKA, Libor SIMUNEK, Oldrich VYSATA, Tran Van QUANG, Michal BAR and Martin VALIS. Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis. \textit{Scientific Reports}. USA: NATURE RESEARCH, 2020, vol.~10, No~1, p.~1-8. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-78434-8.
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