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@article{1738507,
author = {Marvanová, Pavlína and Padrtová, Tereza and Mokrý, Petr},
article_location = {Sharjah},
article_number = {17},
doi = {http://dx.doi.org/10.2174/1389557520666200624192859},
keywords = {Aryloxyphenylpiperazinylpropanols; cardiovascular system; chirality; connecting chain modification; N-phenylpiperazine; biological activities},
language = {eng},
issn = {1389-5575},
journal = {Mini-reviews in medicinal chemistry},
title = {(Hetero)Aryloxyaminopropanols with N-Phenylpiperazine Structural Fragment - Review of Cardiovascular Activity},
url = {https://pubmed.ncbi.nlm.nih.gov/32579495/},
volume = {20},
year = {2020}
}
TY - JOUR
ID - 1738507
AU - Marvanová, Pavlína - Padrtová, Tereza - Mokrý, Petr
PY - 2020
TI - (Hetero)Aryloxyaminopropanols with N-Phenylpiperazine Structural Fragment - Review of Cardiovascular Activity
JF - Mini-reviews in medicinal chemistry
VL - 20
IS - 17
SP - 1719-1731
EP - 1719-1731
PB - Betham Science Publ Ltd.
SN - 13895575
KW - Aryloxyphenylpiperazinylpropanols
KW - cardiovascular system
KW - chirality
KW - connecting chain modification
KW - N-phenylpiperazine
KW - biological activities
UR - https://pubmed.ncbi.nlm.nih.gov/32579495/
L2 - https://pubmed.ncbi.nlm.nih.gov/32579495/
N2 - Aryloxyphenylpiperazinylpropanols are a group of compounds exhibiting a wide range of biological activities, affecting the central nervous system and many cardiovascular mechanisms among them. As cardiovascular agents, aryloxyphenylpiperazinylpropanols work as antihypertensives, antiarrhythmics, cardiotonics or antiaggregants. The mechanism of action is almost always an alpha(1)-adrenolytic or combined alpha(1)- and beta-adrenolytic effect, but sometimes other mechanisms (e.g., Ca2+ antagonism or phosphodiesterase inhibition) can positively participate. In some cases, compounds with a small modification of the connecting chain also exhibit the desired cardiovascular effects. Several studies dealt with chirality of aryloxyphenylpiperazinylpropanols and determined the differences between the particular activities of racemic and enantiomeric compounds.
ER -
MARVANOVÁ, Pavlína, Tereza PADRTOVÁ and Petr MOKRÝ. (Hetero)Aryloxyaminopropanols with N-Phenylpiperazine Structural Fragment - Review of Cardiovascular Activity. \textit{Mini-reviews in medicinal chemistry}. Sharjah: Betham Science Publ Ltd., 2020, vol.~20, No~17, p.~1719-1731. ISSN~1389-5575. Available from: https://dx.doi.org/10.2174/1389557520666200624192859.
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