The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects

FARKAS, A., F. LIZAL, J. JEDELSKY, J. ELCNER, Jakub KARAS, M. BELKA, O. MISIK and M. JICHA. The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects. Journal of Aerosol Science. OXFORD: ELSEVIER SCI LTD, 2020, vol. 147, No 105582, p. 1-16. ISSN 0021-8502. Available from: https://dx.doi.org/10.1016/j.jaerosci.2020.105582.

Basic information

• Original name: The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects
• Authors: FARKAS, A., F. LIZAL, J. JEDELSKY, J. ELCNER, Jakub KARAS (203 Czech Republic, belonging to the institution), M. BELKA, O. MISIK and M. JICHA.
• Edition: Journal of Aerosol Science, OXFORD, ELSEVIER SCI LTD, 2020, 0021-8502.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.433
• RIV identification code: RIV/00216224:14160/20:00118115
• Organization unit: Faculty of Pharmacy
• Doi: http://dx.doi.org/10.1016/j.jaerosci.2020.105582
• UT WoS: 000540032700004
• Keywords in English: AEROSOL DEPOSITION; HUMAN AIRWAYS; LUNG-FUNCTION; FLOW
• Tags: rivok, ÚFT
• Tags: International impact, Reviewed

Abstract

Quantification of airway deposition of aerosol particles is essential for the assessment of health risks of detrimental particles. Knowledge of deposition distribution is important also in the case of treatment with aerosolised drugs. It is also worth considering that deposition of inhaled particles in severe asthmatics can be different from the deposition in healthy subjects due to the modified breathing parameters, airway geometry and lobar flow distribution. The aim of this study was to apply combined experimental and numerical techniques to quantify the upper airway and bronchial deposition of the inhaled microparticles in healthy individuals in comparison with asthma patients. Idealised and realistic physical and digital replicas of the human airways were constructed. Deposition fractions and efficiencies of inhaled polydisperse mannitol and chitosan particles in different airway sections were measured and calculated. Deposition fraction of polydisperse mannitol particles in the idealised airway geometry assuming breathing conditions of healthy subjects was 21.9% and 18.3% when determined experimentally and by numerical simulations, respectively. Experimental measurements of deposition fraction of chitosan particles in the same geometry, but assuming breathing parameters characteristic of severe asthmatics yielded 32%, while simulations provided 30.1% for the same conditions. Extrathoracic deposition fraction of mannitol particles in healthy subjects measured in the realistic geometry was 71.1%, while bronchial deposition fraction was 5.3%. The corresponding simulations yielded 76.2% and 8.9% deposition fractions in the upper and bronchial airways, respectively.

Abstract (in Czech)

Quantification of airway deposition of aerosol particles is essential for the assessment of health risks of detrimental particles. Knowledge of deposition distribution is important also in the case of treatment with aerosolised drugs. It is also worth considering that deposition of inhaled particles in severe asthmatics can be different from the deposition in healthy subjects due to the modified breathing parameters, airway geometry and lobar flow distribution.