HOŘAVOVÁ, Hana, Jan GAJDZIOK and David VETCHÝ. Typy a příprava lipozomálních přípravků pro plicní podání (Types and Preparation of Liposomal Formulations for Pulmonary Administration). CHEMICKÉ LISTY. Praha: Česká společnost chemická, 2020, vol. 114, No 5, p. 322-328. ISSN 0009-2770.
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Basic information
Original name Typy a příprava lipozomálních přípravků pro plicní podání
Name (in English) Types and Preparation of Liposomal Formulations for Pulmonary Administration
Authors HOŘAVOVÁ, Hana (203 Czech Republic, belonging to the institution), Jan GAJDZIOK (203 Czech Republic, belonging to the institution) and David VETCHÝ (203 Czech Republic, belonging to the institution).
Edition CHEMICKÉ LISTY, Praha, Česká společnost chemická, 2020, 0009-2770.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 0.381
RIV identification code RIV/00216224:14160/20:00118116
Organization unit Faculty of Pharmacy
UT WoS 000531098900002
Keywords in English liposomes; lung application; spray drying; lyophylization; dry powder formulations; protectants
Tags rivok, ÚFT
Tags International impact, Reviewed
Changed by Changed by: Mgr. Hana Hurtová, učo 244985. Changed: 26/2/2021 11:17.
Abstract
The use of liposomes as carriers for different types of drugs in formulations to be administered to the lungs brings a number of advantages, including the possibility of controlled release, prolongation of retention at the site of action or reduced systemic exposure. However, the main disadvantage of liposomal suspensions is their physical and chemical instability. Therefore, they are preferably converted to dry powders by several drying technologies. In doing so, it is necessary to include specific excipients in the formulation, in particular protectants (saccharides), protecting liposomes from changes during these processes.
Abstract (in English)
The use of liposomes as carriers for different types of drugs in formulations to be administered to the lungs brings a number of advantages, including the possibility of controlled release, prolongation of retention at the site of action or reduced systemic exposure. However, the main disadvantage of liposomal suspensions is their physical and chemical instability. Therefore, they are preferably converted to dry powders by several drying technologies. In doing so, it is necessary to include specific excipients in the formulation, in particular protectants (saccharides), protecting liposomes from changes during these processes.
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