Detailed Information on Publication Record
2020
Typy a příprava lipozomálních přípravků pro plicní podání
HOŘAVOVÁ, Hana, Jan GAJDZIOK and David VETCHÝBasic information
Original name
Typy a příprava lipozomálních přípravků pro plicní podání
Name (in English)
Types and Preparation of Liposomal Formulations for Pulmonary Administration
Authors
HOŘAVOVÁ, Hana (203 Czech Republic, belonging to the institution), Jan GAJDZIOK (203 Czech Republic, belonging to the institution) and David VETCHÝ (203 Czech Republic, belonging to the institution)
Edition
CHEMICKÉ LISTY, Praha, Česká společnost chemická, 2020, 0009-2770
Other information
Language
Czech
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 0.381
RIV identification code
RIV/00216224:14160/20:00118116
Organization unit
Faculty of Pharmacy
UT WoS
000531098900002
Keywords in English
liposomes; lung application; spray drying; lyophylization; dry powder formulations; protectants
Tags
International impact, Reviewed
Změněno: 26/2/2021 11:17, Mgr. Hana Hurtová
V originále
The use of liposomes as carriers for different types of drugs in formulations to be administered to the lungs brings a number of advantages, including the possibility of controlled release, prolongation of retention at the site of action or reduced systemic exposure. However, the main disadvantage of liposomal suspensions is their physical and chemical instability. Therefore, they are preferably converted to dry powders by several drying technologies. In doing so, it is necessary to include specific excipients in the formulation, in particular protectants (saccharides), protecting liposomes from changes during these processes.
In English
The use of liposomes as carriers for different types of drugs in formulations to be administered to the lungs brings a number of advantages, including the possibility of controlled release, prolongation of retention at the site of action or reduced systemic exposure. However, the main disadvantage of liposomal suspensions is their physical and chemical instability. Therefore, they are preferably converted to dry powders by several drying technologies. In doing so, it is necessary to include specific excipients in the formulation, in particular protectants (saccharides), protecting liposomes from changes during these processes.