Resting-State Phase-Amplitude Coupling Between the Human
Subthalamic Nucleus and Cortical Activity: A Simultaneous
Intracranial and Scalp EEG Study

J 2021

Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study

DAMBORSKÁ, Alena; Martin LAMOŠ; D. BRUNET; S. VULLIEMOZ; Martina BOČKOVÁ et. al.

Basic information

Original name

Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study

Authors

DAMBORSKÁ, Alena (203 Czech Republic, belonging to the institution); Martin LAMOŠ (203 Czech Republic, belonging to the institution); D. BRUNET; S. VULLIEMOZ; Martina BOČKOVÁ (203 Czech Republic, belonging to the institution); Barbora DEUTSCHOVÁ (203 Czech Republic, belonging to the institution); Marek BALÁŽ (703 Slovakia, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

BRAIN TOPOGRAPHY, DORDRECHT, SPRINGER, 2021, 0896-0267

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30210 Clinical neurology

Country of publisher

Netherlands

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 4.275

RIV identification code

RIV/00216224:14740/21:00118858

Organization unit

Central European Institute of Technology

DOI

https://doi.org/10.1007/s10548-021-00822-8

UT WoS

000612889400001

EID Scopus

2-s2.0-85099960294

Keywords in English

Subthalamic nucleus; Subcortico-cortical interactions; Phase-amplitude coupling; Cross-structural coupling; Simultaneous intracranial and scalp EEG

Abstract

In the original language

It has been suggested that slow oscillations in the subthalamic nucleus (STN) reflect top-down inputs from the medial prefrontal cortex, thus implementing behavior control. It is unclear, however, whether the STN oscillations are related to cortical activity in a bottom-up manner. To assess resting-state subcortico-cortical interactions, we recorded simultaneous scalp electroencephalographic activity and local field potentials in the STN (LFP-STN) in 11 patients with Parkinson's disease implanted with deep brain stimulation electrodes in the on-medication state during rest. We assessed the cross-structural phase-amplitude coupling (PAC) between the STN and cortical activity within a wide frequency range of 1 to 100 Hz. The PAC was dominant between the delta/theta STN phase and beta/gamma cortical amplitude in most investigated scalp regions and between the delta cortical phase and theta/alpha STN amplitude in the frontal and temporal regions. The cross-frequency linkage between the slow oscillations of the LFP-STN activity and the amplitude of the scalp-recorded cortical activity at rest was demonstrated, and similar involvement of the left and right STNs in the coupling was observed. Our results suggest that the STN plays a role in both bottom-up and top-down processes within the subcortico-cortical circuitries of the human brain during the resting state. A relative left-right symmetry in the STN-cortex functional linkage was suggested. Practical treatment studies would be necessary to assess whether unilateral stimulation of the STN might be sufficient for treatment of Parkinson's disease.

Links

GA21-25953S, research and development project

Name: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace (Acronym: DBS3D)

Investor: Czech Science Foundation, Subcortical nuclei and cortical functions – insight from the deep brain stimulation perspective

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Cite

DAMBORSKÁ, Alena; Martin LAMOŠ; D. BRUNET; S. VULLIEMOZ; Martina BOČKOVÁ; Barbora DEUTSCHOVÁ; Marek BALÁŽ and Ivan REKTOR. Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study. BRAIN TOPOGRAPHY. DORDRECHT: SPRINGER, 2021, vol. 34, No 3, p. 272-282. ISSN 0896-0267. Available from: https://doi.org/10.1007/s10548-021-00822-8.

@article{1742258,
   author = {Damborská, Alena and Lamoš, Martin and Brunet, D. and Vulliemoz, S. and Bočková, Martina and Deutschová, Barbora and Baláž, Marek and Rektor, Ivan},
   article_location = {DORDRECHT},
   article_number = {3},
   doi = {https://doi.org/10.1007/s10548-021-00822-8},
   keywords = {Subthalamic nucleus; Subcortico-cortical interactions; Phase-amplitude coupling; Cross-structural coupling; Simultaneous intracranial and scalp EEG},
   language = {eng},
   issn = {0896-0267},
   journal = {BRAIN TOPOGRAPHY},
   title = {Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study},
   url = {https://link.springer.com/article/10.1007/s10548-021-00822-8},
   volume = {34},
   year = {2021}
}

TY  - JOUR
ID  - 1742258
AU  - Damborská, Alena - Lamoš, Martin - Brunet, D. - Vulliemoz, S. - Bočková, Martina - Deutschová, Barbora - Baláž, Marek - Rektor, Ivan
PY  - 2021
TI  - Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study
JF  - BRAIN TOPOGRAPHY
VL  - 34
IS  - 3
SP  - 272-282
EP  - 272-282
PB  - SPRINGER
SN  - 08960267
KW  - Subthalamic nucleus
KW  - Subcortico-cortical interactions
KW  - Phase-amplitude coupling
KW  - Cross-structural coupling
KW  - Simultaneous intracranial and scalp EEG
UR  - https://link.springer.com/article/10.1007/s10548-021-00822-8
L2  - https://link.springer.com/article/10.1007/s10548-021-00822-8
N2  - It has been suggested that slow oscillations in the subthalamic nucleus (STN) reflect top-down inputs from the medial prefrontal cortex, thus implementing behavior control. It is unclear, however, whether the STN oscillations are related to cortical activity in a bottom-up manner. To assess resting-state subcortico-cortical interactions, we recorded simultaneous scalp electroencephalographic activity and local field potentials in the STN (LFP-STN) in 11 patients with Parkinson's disease implanted with deep brain stimulation electrodes in the on-medication state during rest. We assessed the cross-structural phase-amplitude coupling (PAC) between the STN and cortical activity within a wide frequency range of 1 to 100 Hz. The PAC was dominant between the delta/theta STN phase and beta/gamma cortical amplitude in most investigated scalp regions and between the delta cortical phase and theta/alpha STN amplitude in the frontal and temporal regions. The cross-frequency linkage between the slow oscillations of the LFP-STN activity and the amplitude of the scalp-recorded cortical activity at rest was demonstrated, and similar involvement of the left and right STNs in the coupling was observed. Our results suggest that the STN plays a role in both bottom-up and top-down processes within the subcortico-cortical circuitries of the human brain during the resting state. A relative left-right symmetry in the STN-cortex functional linkage was suggested. Practical treatment studies would be necessary to assess whether unilateral stimulation of the STN might be sufficient for treatment of Parkinson's disease.
ER  -

DAMBORSKÁ, Alena; Martin LAMOŠ; D. BRUNET; S. VULLIEMOZ; Martina BOČKOVÁ; Barbora DEUTSCHOVÁ; Marek BALÁŽ and Ivan REKTOR. Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study. \textit{BRAIN TOPOGRAPHY}. DORDRECHT: SPRINGER, 2021, vol.~34, No~3, p.~272-282. ISSN~0896-0267. Available from: https://doi.org/10.1007/s10548-021-00822-8.

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