Resting-State Phase-Amplitude Coupling Between the Human
Subthalamic Nucleus and Cortical Activity: A Simultaneous
Intracranial and Scalp EEG Study

J 2021

Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study

DAMBORSKÁ, Alena, Martin LAMOŠ, D. BRUNET, S. VULLIEMOZ, Martina BOČKOVÁ et. al.

Basic information

Original name

Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study

Authors

DAMBORSKÁ, Alena (203 Czech Republic, belonging to the institution), Martin LAMOŠ (203 Czech Republic, belonging to the institution), D. BRUNET, S. VULLIEMOZ, Martina BOČKOVÁ (203 Czech Republic, belonging to the institution), Barbora DEUTSCHOVÁ (203 Czech Republic, belonging to the institution), Marek BALÁŽ (703 Slovakia, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

BRAIN TOPOGRAPHY, DORDRECHT, SPRINGER, 2021, 0896-0267

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.275

RIV identification code

RIV/00216224:14740/21:00118858

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1007/s10548-021-00822-8

UT WoS

000612889400001

Keywords in English

Subthalamic nucleus; Subcortico-cortical interactions; Phase-amplitude coupling; Cross-structural coupling; Simultaneous intracranial and scalp EEG

Abstract

V originále

It has been suggested that slow oscillations in the subthalamic nucleus (STN) reflect top-down inputs from the medial prefrontal cortex, thus implementing behavior control. It is unclear, however, whether the STN oscillations are related to cortical activity in a bottom-up manner. To assess resting-state subcortico-cortical interactions, we recorded simultaneous scalp electroencephalographic activity and local field potentials in the STN (LFP-STN) in 11 patients with Parkinson's disease implanted with deep brain stimulation electrodes in the on-medication state during rest. We assessed the cross-structural phase-amplitude coupling (PAC) between the STN and cortical activity within a wide frequency range of 1 to 100 Hz. The PAC was dominant between the delta/theta STN phase and beta/gamma cortical amplitude in most investigated scalp regions and between the delta cortical phase and theta/alpha STN amplitude in the frontal and temporal regions. The cross-frequency linkage between the slow oscillations of the LFP-STN activity and the amplitude of the scalp-recorded cortical activity at rest was demonstrated, and similar involvement of the left and right STNs in the coupling was observed. Our results suggest that the STN plays a role in both bottom-up and top-down processes within the subcortico-cortical circuitries of the human brain during the resting state. A relative left-right symmetry in the STN-cortex functional linkage was suggested. Practical treatment studies would be necessary to assess whether unilateral stimulation of the STN might be sufficient for treatment of Parkinson's disease.

Links

GA21-25953S, research and development project

Name: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace (Acronym: DBS3D)

Investor: Czech Science Foundation, Subcortical nuclei and cortical functions – insight from the deep brain stimulation perspective

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

DAMBORSKÁ, Alena, Martin LAMOŠ, D. BRUNET, S. VULLIEMOZ, Martina BOČKOVÁ, Barbora DEUTSCHOVÁ, Marek BALÁŽ and Ivan REKTOR. Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study. BRAIN TOPOGRAPHY. DORDRECHT: SPRINGER, 2021, vol. 34, No 3, p. 272-282. ISSN 0896-0267. Available from: https://dx.doi.org/10.1007/s10548-021-00822-8.

@article{1742258,
   author = {Damborská, Alena and Lamoš, Martin and Brunet, D. and Vulliemoz, S. and Bočková, Martina and Deutschová, Barbora and Baláž, Marek and Rektor, Ivan},
   article_location = {DORDRECHT},
   article_number = {3},
   doi = {http://dx.doi.org/10.1007/s10548-021-00822-8},
   keywords = {Subthalamic nucleus; Subcortico-cortical interactions; Phase-amplitude coupling; Cross-structural coupling; Simultaneous intracranial and scalp EEG},
   language = {eng},
   issn = {0896-0267},
   journal = {BRAIN TOPOGRAPHY},
   title = {Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study},
   url = {https://link.springer.com/article/10.1007/s10548-021-00822-8},
   volume = {34},
   year = {2021}
}

TY  - JOUR
ID  - 1742258
AU  - Damborská, Alena - Lamoš, Martin - Brunet, D. - Vulliemoz, S. - Bočková, Martina - Deutschová, Barbora - Baláž, Marek - Rektor, Ivan
PY  - 2021
TI  - Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study
JF  - BRAIN TOPOGRAPHY
VL  - 34
IS  - 3
SP  - 272-282
EP  - 272-282
PB  - SPRINGER
SN  - 08960267
KW  - Subthalamic nucleus
KW  - Subcortico-cortical interactions
KW  - Phase-amplitude coupling
KW  - Cross-structural coupling
KW  - Simultaneous intracranial and scalp EEG
UR  - https://link.springer.com/article/10.1007/s10548-021-00822-8
L2  - https://link.springer.com/article/10.1007/s10548-021-00822-8
N2  - It has been suggested that slow oscillations in the subthalamic nucleus (STN) reflect top-down inputs from the medial prefrontal cortex, thus implementing behavior control. It is unclear, however, whether the STN oscillations are related to cortical activity in a bottom-up manner. To assess resting-state subcortico-cortical interactions, we recorded simultaneous scalp electroencephalographic activity and local field potentials in the STN (LFP-STN) in 11 patients with Parkinson's disease implanted with deep brain stimulation electrodes in the on-medication state during rest. We assessed the cross-structural phase-amplitude coupling (PAC) between the STN and cortical activity within a wide frequency range of 1 to 100 Hz. The PAC was dominant between the delta/theta STN phase and beta/gamma cortical amplitude in most investigated scalp regions and between the delta cortical phase and theta/alpha STN amplitude in the frontal and temporal regions. The cross-frequency linkage between the slow oscillations of the LFP-STN activity and the amplitude of the scalp-recorded cortical activity at rest was demonstrated, and similar involvement of the left and right STNs in the coupling was observed. Our results suggest that the STN plays a role in both bottom-up and top-down processes within the subcortico-cortical circuitries of the human brain during the resting state. A relative left-right symmetry in the STN-cortex functional linkage was suggested. Practical treatment studies would be necessary to assess whether unilateral stimulation of the STN might be sufficient for treatment of Parkinson's disease.
ER  -

DAMBORSKÁ, Alena, Martin LAMOŠ, D. BRUNET, S. VULLIEMOZ, Martina BOČKOVÁ, Barbora DEUTSCHOVÁ, Marek BALÁŽ and Ivan REKTOR. Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study. \textit{BRAIN TOPOGRAPHY}. DORDRECHT: SPRINGER, 2021, vol.~34, No~3, p.~272-282. ISSN~0896-0267. Available from: https://dx.doi.org/10.1007/s10548-021-00822-8.

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