Matrix Vaginal Rings for Female Dogs-Effect of Altering
Dimensions on Mechanical Properties and Dissolution
Characteristics, and In vivo Safety Study

J 2020

Matrix Vaginal Rings for Female Dogs-Effect of Altering Dimensions on Mechanical Properties and Dissolution Characteristics, and In vivo Safety Study

NOVÁKOVÁ TKADLEČKOVÁ, Veronika, V. PITRONOVA, Kateřina KUBOVÁ, Sylvie PAVLOKOVÁ, Jan ELBL et. al.

Basic information

Original name

Matrix Vaginal Rings for Female Dogs-Effect of Altering Dimensions on Mechanical Properties and Dissolution Characteristics, and In vivo Safety Study

Authors

NOVÁKOVÁ TKADLEČKOVÁ, Veronika (203 Czech Republic, belonging to the institution), V. PITRONOVA, Kateřina KUBOVÁ (203 Czech Republic, belonging to the institution), Sylvie PAVLOKOVÁ (203 Czech Republic, belonging to the institution), Jan ELBL (203 Czech Republic, belonging to the institution), R. NOVOTNY, David VETCHÝ (203 Czech Republic, belonging to the institution) and Jakub VYSLOUŽIL (203 Czech Republic, belonging to the institution)

Edition

AAPS PHARMSCITECH, NEW YORK, SPRINGER, 2020, 1530-9932

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.246

RIV identification code

RIV/00216224:14160/20:00118184

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.1208/s12249-020-01770-5

UT WoS

000561298000002

Keywords in English

silicone elastomer; vaginal ring; dimension parameters; DOE; design of experiment; drug release

Abstract

V originále

The vaginal rings research is almost exclusively focused on rings for human medicine, although the dosage form offers improvement of therapeutic effect in other mammals as well. This contribution studied an effect of varying dimension parameters (diameter 20, 30 or 40 mm; height 3, 4 or 5 mm; width of annulus 5, 7.5 or 10 mm) on mechanical properties and dissolution behaviour of silicone vaginal rings with constant drug amount, intended for use in dogs. Results showed that altering dimensions influenced mechanical properties (compressive force, tensile strength and resistance of removal thread),in vitrodrug release and water uptake. The removal thread resistance was increasing with increasing height and width. Compression force was higher for the rings with smaller diameter. The total drug release was increasing with decreasing height and rising diameter, surface area and water uptake during dissolution test. The initial dissolution rate was slower for the rings with higher width. As the best candidate for use in model dog subjects, the ring with 30 mm diameter, 3 mm height and 7.5 mm width was found. These drug-free vaginal rings were further tested inin vivosafety study. The results did not show any major deviation from the physiological conditions.

Citovat

NOVÁKOVÁ TKADLEČKOVÁ, Veronika, V. PITRONOVA, Kateřina KUBOVÁ, Sylvie PAVLOKOVÁ, Jan ELBL, R. NOVOTNY, David VETCHÝ and Jakub VYSLOUŽIL. Matrix Vaginal Rings for Female Dogs-Effect of Altering Dimensions on Mechanical Properties and Dissolution Characteristics, and In vivo Safety Study. AAPS PHARMSCITECH. NEW YORK: SPRINGER, 2020, vol. 21, No 6, p. 1-12. ISSN 1530-9932. Available from: https://dx.doi.org/10.1208/s12249-020-01770-5.

@article{1742761,
   author = {Nováková Tkadlečková, Veronika and Pitronova, V. and Kubová, Kateřina and Pavloková, Sylvie and Elbl, Jan and Novotny, R. and Vetchý, David and Vysloužil, Jakub},
   article_location = {NEW YORK},
   article_number = {6},
   doi = {http://dx.doi.org/10.1208/s12249-020-01770-5},
   keywords = {silicone elastomer; vaginal ring; dimension parameters; DOE; design of experiment; drug release},
   language = {eng},
   issn = {1530-9932},
   journal = {AAPS PHARMSCITECH},
   title = {Matrix Vaginal Rings for Female Dogs-Effect of Altering Dimensions on Mechanical Properties and Dissolution Characteristics, and In vivo Safety Study},
   url = {https://link.springer.com/article/10.1208/s12249-020-01770-5},
   volume = {21},
   year = {2020}
}

TY  - JOUR
ID  - 1742761
AU  - Nováková Tkadlečková, Veronika - Pitronova, V. - Kubová, Kateřina - Pavloková, Sylvie - Elbl, Jan - Novotny, R. - Vetchý, David - Vysloužil, Jakub
PY  - 2020
TI  - Matrix Vaginal Rings for Female Dogs-Effect of Altering Dimensions on Mechanical Properties and Dissolution Characteristics, and In vivo Safety Study
JF  - AAPS PHARMSCITECH
VL  - 21
IS  - 6
SP  - 1-12
EP  - 1-12
PB  - SPRINGER
SN  - 15309932
KW  - silicone elastomer
KW  - vaginal ring
KW  - dimension parameters
KW  - DOE
KW  - design of experiment
KW  - drug release
UR  - https://link.springer.com/article/10.1208/s12249-020-01770-5
L2  - https://link.springer.com/article/10.1208/s12249-020-01770-5
N2  - The vaginal rings research is almost exclusively focused on rings for human medicine, although the dosage form offers improvement of therapeutic effect in other mammals as well. This contribution studied an effect of varying dimension parameters (diameter 20, 30 or 40 mm; height 3, 4 or 5 mm; width of annulus 5, 7.5 or 10 mm) on mechanical properties and dissolution behaviour of silicone vaginal rings with constant drug amount, intended for use in dogs. Results showed that altering dimensions influenced mechanical properties (compressive force, tensile strength and resistance of removal thread),in vitrodrug release and water uptake. The removal thread resistance was increasing with increasing height and width. Compression force was higher for the rings with smaller diameter. The total drug release was increasing with decreasing height and rising diameter, surface area and water uptake during dissolution test. The initial dissolution rate was slower for the rings with higher width. As the best candidate for use in model dog subjects, the ring with 30 mm diameter, 3 mm height and 7.5 mm width was found. These drug-free vaginal rings were further tested inin vivosafety study. The results did not show any major deviation from the physiological conditions.
ER  -

NOVÁKOVÁ TKADLEČKOVÁ, Veronika, V. PITRONOVA, Kateřina KUBOVÁ, Sylvie PAVLOKOVÁ, Jan ELBL, R. NOVOTNY, David VETCHÝ and Jakub VYSLOUŽIL. Matrix Vaginal Rings for Female Dogs-Effect of Altering Dimensions on Mechanical Properties and Dissolution Characteristics, and In vivo Safety Study. \textit{AAPS PHARMSCITECH}. NEW YORK: SPRINGER, 2020, vol.~21, No~6, p.~1-12. ISSN~1530-9932. Available from: https://dx.doi.org/10.1208/s12249-020-01770-5.

Detailed Information on Publication Record