Natural Compounds Rosmarinic Acid and Carvacrol Counteract
Aluminium-Induced Oxidative Stress

J 2020

Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress

BARANAUSKAITE, J., I. SADAUSKIENE, A. LIEKIS, A. KASAUSKAS, R. LAZAUSKAS et. al.

Basic information

Original name

Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress

Authors

BARANAUSKAITE, J., I. SADAUSKIENE, A. LIEKIS, A. KASAUSKAS, R. LAZAUSKAS, U. ZLABIENE (guarantor), Ruta MASTEIKOVÁ (203 Czech Republic, belonging to the institution), D. M. KOPUSTINSKIENE and J. BERNATONIENE

Edition

Molecules, Orlando, Florida, Academic Press, 2020, 1079-9796

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.039

RIV identification code

RIV/00216224:14160/20:00118195

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/molecules25081807

UT WoS

000534617300029

Keywords in English

aluminum toxicity; rosmarinic acid; carvacrol; oxidative stress; lipid peroxidation; brain; liver

Abstract

V originále

Aluminum accumulation, glutathione (GSH) and malondialdehyde (MDA) concentrations as well as catalase (CAT) and superoxide dismutase (SOD) activities were determined in erythrocytes and brain and liver homogenates of BALB/c mice treated with Al3+ (7.5 mg/kg/day (0.15 LD50) as AlCl3 (37.08 mg/kg/day), whereas HCl (30.41 mg/kg/day) was used as Cl control, the treatments were performed for 21 days, i.p., in the presence and absence of rosmarinic acid (0.2805 mg/kg/day (0.05 LD50), 21 days, i.g.) or carvacrol (0.0405 mg/kg/day (0.05 LD50), 21 days, i.g.). The treatment with AlCl3 increased GSH concentration in erythrocytes only slightly and had no effect on brain and liver homogenates. Rosmarinic acid and carvacrol strongly increased GSH concentration in erythrocytes but decreased it in brain and liver homogenates. However, AlCl3 treatment led to Al accumulation in mice blood, brain, and liver and induced oxidative stress, assessed based on MDA concentration in the brain and liver. Both rosmarinic acid and carvacrol were able to counteract the negative Al effect by decreasing its accumulation and protecting tissues from lipid peroxidation. AlCl3 treatment increased CAT activity in mice brain and liver homogenates, whereas the administration of either rosmarinic acid or carvacrol alone or in combination with AlCl3 had no significant effect on CAT activity. SOD activity remained unchanged after all the treatments in our study. We propose that natural herbal phenolic compounds rosmarinic acid and carvacrol could be used to protect brain and liver against aluminum induced oxidative stress leading to lipid peroxidation.

Citovat

BARANAUSKAITE, J., I. SADAUSKIENE, A. LIEKIS, A. KASAUSKAS, R. LAZAUSKAS, U. ZLABIENE, Ruta MASTEIKOVÁ, D. M. KOPUSTINSKIENE and J. BERNATONIENE. Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress. Molecules. Orlando, Florida: Academic Press, 2020, vol. 25, No 8, p. 1-13. ISSN 1079-9796. Available from: https://dx.doi.org/10.3390/molecules25081807.

@article{1743520,
   author = {Baranauskaite, J. and Sadauskiene, I. and Liekis, A. and Kasauskas, A. and Lazauskas, R. and Zlabiene, U. and Masteiková, Ruta and Kopustinskiene, D. M. and Bernatoniene, J.},
   article_location = {Orlando, Florida},
   article_number = {8},
   doi = {http://dx.doi.org/10.3390/molecules25081807},
   keywords = {aluminum toxicity; rosmarinic acid; carvacrol; oxidative stress; lipid peroxidation; brain; liver},
   language = {eng},
   issn = {1079-9796},
   journal = {Molecules},
   title = {Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress},
   url = {https://www.mdpi.com/1420-3049/25/8/1807},
   volume = {25},
   year = {2020}
}

TY  - JOUR
ID  - 1743520
AU  - Baranauskaite, J. - Sadauskiene, I. - Liekis, A. - Kasauskas, A. - Lazauskas, R. - Zlabiene, U. - Masteiková, Ruta - Kopustinskiene, D. M. - Bernatoniene, J.
PY  - 2020
TI  - Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress
JF  - Molecules
VL  - 25
IS  - 8
SP  - 1-13
EP  - 1-13
PB  - Academic Press
SN  - 10799796
KW  - aluminum toxicity
KW  - rosmarinic acid
KW  - carvacrol
KW  - oxidative stress
KW  - lipid peroxidation
KW  - brain
KW  - liver
UR  - https://www.mdpi.com/1420-3049/25/8/1807
L2  - https://www.mdpi.com/1420-3049/25/8/1807
N2  - Aluminum accumulation, glutathione (GSH) and malondialdehyde (MDA) concentrations as well as catalase (CAT) and superoxide dismutase (SOD) activities were determined in erythrocytes and brain and liver homogenates of BALB/c mice treated with Al3+ (7.5 mg/kg/day (0.15 LD50) as AlCl3 (37.08 mg/kg/day), whereas HCl (30.41 mg/kg/day) was used as Cl control, the treatments were performed for 21 days, i.p., in the presence and absence of rosmarinic acid (0.2805 mg/kg/day (0.05 LD50), 21 days, i.g.) or carvacrol (0.0405 mg/kg/day (0.05 LD50), 21 days, i.g.). The treatment with AlCl3 increased GSH concentration in erythrocytes only slightly and had no effect on brain and liver homogenates. Rosmarinic acid and carvacrol strongly increased GSH concentration in erythrocytes but decreased it in brain and liver homogenates. However, AlCl3 treatment led to Al accumulation in mice blood, brain, and liver and induced oxidative stress, assessed based on MDA concentration in the brain and liver. Both rosmarinic acid and carvacrol were able to counteract the negative Al effect by decreasing its accumulation and protecting tissues from lipid peroxidation. AlCl3 treatment increased CAT activity in mice brain and liver homogenates, whereas the administration of either rosmarinic acid or carvacrol alone or in combination with AlCl3 had no significant effect on CAT activity. SOD activity remained unchanged after all the treatments in our study. We propose that natural herbal phenolic compounds rosmarinic acid and carvacrol could be used to protect brain and liver against aluminum induced oxidative stress leading to lipid peroxidation.
ER  -

BARANAUSKAITE, J., I. SADAUSKIENE, A. LIEKIS, A. KASAUSKAS, R. LAZAUSKAS, U. ZLABIENE, Ruta MASTEIKOVÁ, D. M. KOPUSTINSKIENE and J. BERNATONIENE. Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress. \textit{Molecules}. Orlando, Florida: Academic Press, 2020, vol.~25, No~8, p.~1-13. ISSN~1079-9796. Available from: https://dx.doi.org/10.3390/molecules25081807.

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