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@article{1743520,
author = {Baranauskaite, J. and Sadauskiene, I. and Liekis, A. and Kasauskas, A. and Lazauskas, R. and Zlabiene, U. and Masteiková, Ruta and Kopustinskiene, D. M. and Bernatoniene, J.},
article_location = {Orlando, Florida},
article_number = {8},
doi = {http://dx.doi.org/10.3390/molecules25081807},
keywords = {aluminum toxicity; rosmarinic acid; carvacrol; oxidative stress; lipid peroxidation; brain; liver},
language = {eng},
issn = {1079-9796},
journal = {Molecules},
title = {Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress},
url = {https://www.mdpi.com/1420-3049/25/8/1807},
volume = {25},
year = {2020}
}
TY - JOUR
ID - 1743520
AU - Baranauskaite, J. - Sadauskiene, I. - Liekis, A. - Kasauskas, A. - Lazauskas, R. - Zlabiene, U. - Masteiková, Ruta - Kopustinskiene, D. M. - Bernatoniene, J.
PY - 2020
TI - Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress
JF - Molecules
VL - 25
IS - 8
SP - 1-13
EP - 1-13
PB - Academic Press
SN - 10799796
KW - aluminum toxicity
KW - rosmarinic acid
KW - carvacrol
KW - oxidative stress
KW - lipid peroxidation
KW - brain
KW - liver
UR - https://www.mdpi.com/1420-3049/25/8/1807
L2 - https://www.mdpi.com/1420-3049/25/8/1807
N2 - Aluminum accumulation, glutathione (GSH) and malondialdehyde (MDA) concentrations as well as catalase (CAT) and superoxide dismutase (SOD) activities were determined in erythrocytes and brain and liver homogenates of BALB/c mice treated with Al3+ (7.5 mg/kg/day (0.15 LD50) as AlCl3 (37.08 mg/kg/day), whereas HCl (30.41 mg/kg/day) was used as Cl control, the treatments were performed for 21 days, i.p., in the presence and absence of rosmarinic acid (0.2805 mg/kg/day (0.05 LD50), 21 days, i.g.) or carvacrol (0.0405 mg/kg/day (0.05 LD50), 21 days, i.g.). The treatment with AlCl3 increased GSH concentration in erythrocytes only slightly and had no effect on brain and liver homogenates. Rosmarinic acid and carvacrol strongly increased GSH concentration in erythrocytes but decreased it in brain and liver homogenates. However, AlCl3 treatment led to Al accumulation in mice blood, brain, and liver and induced oxidative stress, assessed based on MDA concentration in the brain and liver. Both rosmarinic acid and carvacrol were able to counteract the negative Al effect by decreasing its accumulation and protecting tissues from lipid peroxidation. AlCl3 treatment increased CAT activity in mice brain and liver homogenates, whereas the administration of either rosmarinic acid or carvacrol alone or in combination with AlCl3 had no significant effect on CAT activity. SOD activity remained unchanged after all the treatments in our study. We propose that natural herbal phenolic compounds rosmarinic acid and carvacrol could be used to protect brain and liver against aluminum induced oxidative stress leading to lipid peroxidation.
ER -
BARANAUSKAITE, J., I. SADAUSKIENE, A. LIEKIS, A. KASAUSKAS, R. LAZAUSKAS, U. ZLABIENE, Ruta MASTEIKOVÁ, D. M. KOPUSTINSKIENE and J. BERNATONIENE. Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress. \textit{Molecules}. Orlando, Florida: Academic Press, 2020, vol.~25, No~8, p.~1-13. ISSN~1079-9796. Available from: https://dx.doi.org/10.3390/molecules25081807.
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