Suboptimal response to STN-DBS in Parkinson's disease can be
identified via reaction times in a motor cognitive paradigm

J 2020

Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm

BOČKOVÁ, Martina, Martin LAMOŠ, Petr KLIMES, Pavel JURAK, Josef HALAMEK et. al.

Basic information

Original name

Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm

Authors

BOČKOVÁ, Martina (203 Czech Republic, belonging to the institution), Martin LAMOŠ (203 Czech Republic, belonging to the institution), Petr KLIMES (203 Czech Republic), Pavel JURAK (203 Czech Republic), Josef HALAMEK (203 Czech Republic), Sabina GOLDEMUNDOVÁ (203 Czech Republic, belonging to the institution), Marek BALÁŽ (703 Slovakia, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Neural Transmission, WIEN, SPRINGER WIEN, 2020, 0300-9564

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Austria

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.575

RIV identification code

RIV/00216224:14740/20:00118223

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1007/s00702-020-02254-3

UT WoS

000572342400001

Keywords in English

HD-EEG; Deep brain stimulation; Reaction time; Time frequency analysis; Biomarkers

Abstract

V originále

Although deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) is generally a successful therapy, adverse events and insufficient clinical effect can complicate the treatment in some patients. We studied clinical parameters and cortical oscillations related to STN-DBS to identify patients with suboptimal responses. High-density EEG was recorded during a visual oddball three-stimuli paradigm in DBS "off" and "on" conditions in 32 PD patients with STN-DBS. Pre-processed data were reconstructed into the source space and the time-frequency analysis was evaluated. We identified a subgroup of six patients with longer reaction times (RT) during the DBS "on" state than in the DBS "off" state after target stimuli. These subjects had lower motor responsiveness to DBS and decreased memory test results compared to the other subjects. Moreover, the alpha and beta power decrease (event-related desynchronizations, ERD), known as an activation correlate linked to motor and cognitive processing, was also reduced in the DBS "on" condition in these patients. A subgroup of PD patients with a suboptimal response to STN-DBS was identified. Evaluation of RT could potentially serve as a biomarker for responsiveness to STN-DBS.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

NV16-33798A, research and development project

Name: Modulace funkční konektivity kortikálních sítí vlivem STN DBS

Citovat

BOČKOVÁ, Martina, Martin LAMOŠ, Petr KLIMES, Pavel JURAK, Josef HALAMEK, Sabina GOLDEMUNDOVÁ, Marek BALÁŽ and Ivan REKTOR. Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm. Journal of Neural Transmission. WIEN: SPRINGER WIEN, 2020, vol. 127, No 12, p. 1579-1588. ISSN 0300-9564. Available from: https://dx.doi.org/10.1007/s00702-020-02254-3.

@article{1744840,
   author = {Bočková, Martina and Lamoš, Martin and Klimes, Petr and Jurak, Pavel and Halamek, Josef and Goldemundová, Sabina and Baláž, Marek and Rektor, Ivan},
   article_location = {WIEN},
   article_number = {12},
   doi = {http://dx.doi.org/10.1007/s00702-020-02254-3},
   keywords = {HD-EEG; Deep brain stimulation; Reaction time; Time frequency analysis; Biomarkers},
   language = {eng},
   issn = {0300-9564},
   journal = {Journal of Neural Transmission},
   title = {Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm},
   url = {https://link.springer.com/article/10.1007%2Fs00702-020-02254-3},
   volume = {127},
   year = {2020}
}

TY  - JOUR
ID  - 1744840
AU  - Bočková, Martina - Lamoš, Martin - Klimes, Petr - Jurak, Pavel - Halamek, Josef - Goldemundová, Sabina - Baláž, Marek - Rektor, Ivan
PY  - 2020
TI  - Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm
JF  - Journal of Neural Transmission
VL  - 127
IS  - 12
SP  - 1579-1588
EP  - 1579-1588
PB  - SPRINGER WIEN
SN  - 03009564
KW  - HD-EEG
KW  - Deep brain stimulation
KW  - Reaction time
KW  - Time frequency analysis
KW  - Biomarkers
UR  - https://link.springer.com/article/10.1007%2Fs00702-020-02254-3
N2  - Although deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) is generally a successful therapy, adverse events and insufficient clinical effect can complicate the treatment in some patients. We studied clinical parameters and cortical oscillations related to STN-DBS to identify patients with suboptimal responses. High-density EEG was recorded during a visual oddball three-stimuli paradigm in DBS "off" and "on" conditions in 32 PD patients with STN-DBS. Pre-processed data were reconstructed into the source space and the time-frequency analysis was evaluated. We identified a subgroup of six patients with longer reaction times (RT) during the DBS "on" state than in the DBS "off" state after target stimuli. These subjects had lower motor responsiveness to DBS and decreased memory test results compared to the other subjects. Moreover, the alpha and beta power decrease (event-related desynchronizations, ERD), known as an activation correlate linked to motor and cognitive processing, was also reduced in the DBS "on" condition in these patients. A subgroup of PD patients with a suboptimal response to STN-DBS was identified. Evaluation of RT could potentially serve as a biomarker for responsiveness to STN-DBS.
ER  -

BOČKOVÁ, Martina, Martin LAMOŠ, Petr KLIMES, Pavel JURAK, Josef HALAMEK, Sabina GOLDEMUNDOVÁ, Marek BALÁŽ and Ivan REKTOR. Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm. \textit{Journal of Neural Transmission}. WIEN: SPRINGER WIEN, 2020, vol.~127, No~12, p.~1579-1588. ISSN~0300-9564. Available from: https://dx.doi.org/10.1007/s00702-020-02254-3.

Detailed Information on Publication Record