Composites of yeast glucan particles and curcumin lead to
improvement of dextran sulfate sodium-induced acute bowel
inflammation in rats

J 2021

Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

ROTREKL, Dominik, P. SALAMUNOVA, Lenka PARÁKOVÁ, Ondrej BAĎO, I. SALON et. al.

Basic information

Original name

Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

Authors

ROTREKL, Dominik (203 Czech Republic, guarantor, belonging to the institution), P. SALAMUNOVA, Lenka PARÁKOVÁ (203 Czech Republic, belonging to the institution), Ondrej BAĎO (703 Slovakia, belonging to the institution), I. SALON, F. STEPANEK, J. HANUS and J. HOSEK

Edition

Carbohydrate Polymers, Oxford, ELSEVIER SCI LTD, 2021, 0144-8617

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 10.723

RIV identification code

RIV/00216224:14160/21:00121162

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.1016/j.carbpol.2020.117142

UT WoS

000596264200008

Keywords in English

Colitis targeting; Curcumin; beta-Glucan; Yeast glucan particles; Inflammation

Abstract

V originále

The goal of this work was to assess the usability of yeast glucan particles (GPs) as carriers for curcumin and determine the beneficial effect of a pharmacological composite of curcumin in GPs on dextran sulfate sodium induced colitis in rats. The assessment of the anti-inflammatory effect of particular substances was evaluated on the basis of the calculated disease activity index and by assessment of cytokines and enzymes from the gut tissue - tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta 1, interleukin (IL)-1 beta, IL-6, IL-10, IL-17, catalase, superoxide dismutase 2, myeloperoxidase (MPO), and matrix metalloproteinase 9. Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-alpha, IL-1 beta, IL-6, and the activity of MPO, as well. The anti-inflammatory effect of the composites was greater than those of pure GPs or curcumin.

Citovat

ROTREKL, Dominik, P. SALAMUNOVA, Lenka PARÁKOVÁ, Ondrej BAĎO, I. SALON, F. STEPANEK, J. HANUS and J. HOSEK. Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats. Carbohydrate Polymers. Oxford: ELSEVIER SCI LTD, 2021, vol. 252, No 117142, p. 1-9. ISSN 0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2020.117142.

@article{1744937,
   author = {Rotrekl, Dominik and Salamunova, P. and Paráková, Lenka and Baďo, Ondrej and Salon, I. and Stepanek, F. and Hanus, J. and Hosek, J.},
   article_location = {Oxford},
   article_number = {117142},
   doi = {http://dx.doi.org/10.1016/j.carbpol.2020.117142},
   keywords = {Colitis targeting; Curcumin; beta-Glucan; Yeast glucan particles; Inflammation},
   language = {eng},
   issn = {0144-8617},
   journal = {Carbohydrate Polymers},
   title = {Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats},
   url = {https://www.sciencedirect.com/science/article/pii/S0144861720313151?via%3Dihub},
   volume = {252},
   year = {2021}
}

TY  - JOUR
ID  - 1744937
AU  - Rotrekl, Dominik - Salamunova, P. - Paráková, Lenka - Baďo, Ondrej - Salon, I. - Stepanek, F. - Hanus, J. - Hosek, J.
PY  - 2021
TI  - Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats
JF  - Carbohydrate Polymers
VL  - 252
IS  - 117142
SP  - 1-9
EP  - 1-9
PB  - ELSEVIER SCI LTD
SN  - 01448617
KW  - Colitis targeting
KW  - Curcumin
KW  - beta-Glucan
KW  - Yeast glucan particles
KW  - Inflammation
UR  - https://www.sciencedirect.com/science/article/pii/S0144861720313151?via%3Dihub
N2  - The goal of this work was to assess the usability of yeast glucan particles (GPs) as carriers for curcumin and determine the beneficial effect of a pharmacological composite of curcumin in GPs on dextran sulfate sodium induced colitis in rats. The assessment of the anti-inflammatory effect of particular substances was evaluated on the basis of the calculated disease activity index and by assessment of cytokines and enzymes from the gut tissue - tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta 1, interleukin (IL)-1 beta, IL-6, IL-10, IL-17, catalase, superoxide dismutase 2, myeloperoxidase (MPO), and matrix metalloproteinase 9. Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-alpha, IL-1 beta, IL-6, and the activity of MPO, as well. The anti-inflammatory effect of the composites was greater than those of pure GPs or curcumin.
ER  -

ROTREKL, Dominik, P. SALAMUNOVA, Lenka PARÁKOVÁ, Ondrej BAĎO, I. SALON, F. STEPANEK, J. HANUS and J. HOSEK. Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats. \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2021, vol.~252, No~117142, p.~1-9. ISSN~0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2020.117142.

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