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@article{1744937,
author = {Rotrekl, Dominik and Salamunova, P. and Paráková, Lenka and Baďo, Ondrej and Salon, I. and Stepanek, F. and Hanus, J. and Hosek, J.},
article_location = {Oxford},
article_number = {117142},
doi = {http://dx.doi.org/10.1016/j.carbpol.2020.117142},
keywords = {Colitis targeting; Curcumin; beta-Glucan; Yeast glucan particles; Inflammation},
language = {eng},
issn = {0144-8617},
journal = {Carbohydrate Polymers},
title = {Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats},
url = {https://www.sciencedirect.com/science/article/pii/S0144861720313151?via%3Dihub},
volume = {252},
year = {2021}
}
TY - JOUR
ID - 1744937
AU - Rotrekl, Dominik - Salamunova, P. - Paráková, Lenka - Baďo, Ondrej - Salon, I. - Stepanek, F. - Hanus, J. - Hosek, J.
PY - 2021
TI - Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats
JF - Carbohydrate Polymers
VL - 252
IS - 117142
SP - 1-9
EP - 1-9
PB - ELSEVIER SCI LTD
SN - 01448617
KW - Colitis targeting
KW - Curcumin
KW - beta-Glucan
KW - Yeast glucan particles
KW - Inflammation
UR - https://www.sciencedirect.com/science/article/pii/S0144861720313151?via%3Dihub
N2 - The goal of this work was to assess the usability of yeast glucan particles (GPs) as carriers for curcumin and determine the beneficial effect of a pharmacological composite of curcumin in GPs on dextran sulfate sodium induced colitis in rats. The assessment of the anti-inflammatory effect of particular substances was evaluated on the basis of the calculated disease activity index and by assessment of cytokines and enzymes from the gut tissue - tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta 1, interleukin (IL)-1 beta, IL-6, IL-10, IL-17, catalase, superoxide dismutase 2, myeloperoxidase (MPO), and matrix metalloproteinase 9. Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-alpha, IL-1 beta, IL-6, and the activity of MPO, as well. The anti-inflammatory effect of the composites was greater than those of pure GPs or curcumin.
ER -
ROTREKL, Dominik, P. SALAMUNOVA, Lenka PARÁKOVÁ, Ondrej BAĎO, I. SALON, F. STEPANEK, J. HANUS and J. HOSEK. Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats. \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2021, vol.~252, No~117142, p.~1-9. ISSN~0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2020.117142.
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