Detailed Information on Publication Record

TREML, Jakub, Markéta GAZDOVÁ, Karel ŠMEJKAL, M. SUDOMOVA, P. KUBATKA and S. T. S. HASSAN. Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development. Viruses-Basel. Basel, Switzerland: MDPI AG, 2020, vol. 12, No 2, p. 1-42. ISSN 1999-4915. Available from: https://dx.doi.org/10.3390/v12020154.

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TY  - JOUR
ID  - 1745776
AU  - Treml, Jakub - Gazdová, Markéta - Šmejkal, Karel - Sudomova, M. - Kubatka, P. - Hassan, S. T. S.
PY  - 2020
TI  - Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development
JF  - Viruses-Basel
VL  - 12
IS  - 2
SP  - 1-42
EP  - 1-42
PB  - MDPI AG
SN  - 19994915
KW  - herpes simplex virus infection
KW  - bioactive natural products
KW  - drug resistance
KW  - drug development
KW  - antiherpetic drugs
KW  - preclinical and clinical studies
KW  - mechanisms of action
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077281/
N2  - Recently, the problem of viral infection, particularly the infection with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), has dramatically increased and caused a significant challenge to public health due to the rising problem of drug resistance. The antiherpetic drug resistance crisis has been attributed to the overuse of these medications, as well as the lack of new drug development by the pharmaceutical industry due to reduced economic inducements and challenging regulatory requirements. Therefore, the development of novel antiviral drugs against HSV infections would be a step forward in improving global combat against these infections. The incorporation of biologically active natural products into anti-HSV drug development at the clinical level has gained limited attention to date. Thus, the search for new drugs from natural products that could enter clinical practice with lessened resistance, less undesirable effects, and various mechanisms of action is greatly needed to break the barriers to novel antiherpetic drug development, which, in turn, will pave the road towards the efficient and safe treatment of HSV infections. In this review, we aim to provide an up-to-date overview of the recent advances in natural antiherpetic agents. Additionally, this paper covers a large scale of phenolic compounds, alkaloids, terpenoids, polysaccharides, peptides, and other miscellaneous compounds derived from various sources of natural origin (plants, marine organisms, microbial sources, lichen species, insects, and mushrooms) with promising activities against HSV infections; these are in vitro and in vivo studies. This work also highlights bioactive natural products that could be used as templates for the further development of anti-HSV drugs at both animal and clinical levels, along with the potential mechanisms by which these compounds induce anti-HSV properties. Future insights into the development of these molecules as safe and effective natural anti-HSV drugs are also debated.
ER  -

Basic information
Original name	Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development
Authors	TREML, Jakub (203 Czech Republic, belonging to the institution), Markéta GAZDOVÁ (203 Czech Republic, belonging to the institution), Karel ŠMEJKAL (203 Czech Republic, belonging to the institution), M. SUDOMOVA, P. KUBATKA and S. T. S. HASSAN (guarantor).
Edition	Viruses-Basel, Basel, Switzerland, MDPI AG, 2020, 1999-4915.

Other information
Original language	English
Type of outcome	Article in a journal
Field of Study	30104 Pharmacology and pharmacy
Country of publisher	Switzerland
Confidentiality degree	is not subject to a state or trade secret
WWW	URL
Impact factor	Impact factor: 5.048
RIV identification code	RIV/00216224:14160/20:00118247
Organization unit	Faculty of Pharmacy
Doi	http://dx.doi.org/10.3390/v12020154
UT WoS	000521256600005
Keywords in English	herpes simplex virus infection; bioactive natural products; drug resistance; drug development; antiherpetic drugs; preclinical and clinical studies; mechanisms of action
Tags	rivok, ÚMF, ÚPL
Tags	International impact, Reviewed
Changed by	Changed by: Mgr. Hana Hurtová, učo 244985. Changed: 24/2/2021 10:56.

Abstract
Recently, the problem of viral infection, particularly the infection with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), has dramatically increased and caused a significant challenge to public health due to the rising problem of drug resistance. The antiherpetic drug resistance crisis has been attributed to the overuse of these medications, as well as the lack of new drug development by the pharmaceutical industry due to reduced economic inducements and challenging regulatory requirements. Therefore, the development of novel antiviral drugs against HSV infections would be a step forward in improving global combat against these infections. The incorporation of biologically active natural products into anti-HSV drug development at the clinical level has gained limited attention to date. Thus, the search for new drugs from natural products that could enter clinical practice with lessened resistance, less undesirable effects, and various mechanisms of action is greatly needed to break the barriers to novel antiherpetic drug development, which, in turn, will pave the road towards the efficient and safe treatment of HSV infections. In this review, we aim to provide an up-to-date overview of the recent advances in natural antiherpetic agents. Additionally, this paper covers a large scale of phenolic compounds, alkaloids, terpenoids, polysaccharides, peptides, and other miscellaneous compounds derived from various sources of natural origin (plants, marine organisms, microbial sources, lichen species, insects, and mushrooms) with promising activities against HSV infections; these are in vitro and in vivo studies. This work also highlights bioactive natural products that could be used as templates for the further development of anti-HSV drugs at both animal and clinical levels, along with the potential mechanisms by which these compounds induce anti-HSV properties. Future insights into the development of these molecules as safe and effective natural anti-HSV drugs are also debated.

Abstract

Recently, the problem of viral infection, particularly the infection with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), has dramatically increased and caused a significant challenge to public health due to the rising problem of drug resistance. The antiherpetic drug resistance crisis has been attributed to the overuse of these medications, as well as the lack of new drug development by the pharmaceutical industry due to reduced economic inducements and challenging regulatory requirements. Therefore, the development of novel antiviral drugs against HSV infections would be a step forward in improving global combat against these infections. The incorporation of biologically active natural products into anti-HSV drug development at the clinical level has gained limited attention to date. Thus, the search for new drugs from natural products that could enter clinical practice with lessened resistance, less undesirable effects, and various mechanisms of action is greatly needed to break the barriers to novel antiherpetic drug development, which, in turn, will pave the road towards the efficient and safe treatment of HSV infections. In this review, we aim to provide an up-to-date overview of the recent advances in natural antiherpetic agents. Additionally, this paper covers a large scale of phenolic compounds, alkaloids, terpenoids, polysaccharides, peptides, and other miscellaneous compounds derived from various sources of natural origin (plants, marine organisms, microbial sources, lichen species, insects, and mushrooms) with promising activities against HSV infections; these are in vitro and in vivo studies. This work also highlights bioactive natural products that could be used as templates for the further development of anti-HSV drugs at both animal and clinical levels, along with the potential mechanisms by which these compounds induce anti-HSV properties. Future insights into the development of these molecules as safe and effective natural anti-HSV drugs are also debated.