Stabilized antioxidative plant extracts formulated by
liquisolid technique

J 2020

Stabilized antioxidative plant extracts formulated by liquisolid technique

KURHAJEC, Slavomír, Klára KOSTELANSKÁ, Sylvie PAVLOKOVÁ, David VETCHÝ, Tomáš WOLASCHKA et. al.

Basic information

Original name

Stabilized antioxidative plant extracts formulated by liquisolid technique

Authors

KURHAJEC, Slavomír (703 Slovakia, belonging to the institution), Klára KOSTELANSKÁ (203 Czech Republic, belonging to the institution), Sylvie PAVLOKOVÁ (203 Czech Republic, belonging to the institution), David VETCHÝ (203 Czech Republic, belonging to the institution), Tomáš WOLASCHKA (703 Slovakia, belonging to the institution), Jan GAJDZIOK (203 Czech Republic, guarantor, belonging to the institution) and Aleš FRANC (203 Czech Republic, belonging to the institution)

Edition

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, AMSTERDAM, ELSEVIER, 2020, 1773-2247

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.981

RIV identification code

RIV/00216224:14160/20:00118250

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.1016/j.jddst.2020.102022

UT WoS

000601051800002

Keywords in English

Neusilin (R); Antioxidant activity; Liquisolid system; Liquid plant extract; Drying process; Partial least squares

Abstract

V originále

Plant extracts with antioxidant activity are an important source of natural drugs. Usually are used as liquids, which are voluminous and often unstable. To overcome these obstacles, fast disintegrating tablets with high content of antioxidants were prepared by an innovative way of dried liquisolid system. The thickened extracts of Aronia melanocarpa, Crataegus leavigata and Rosa canina (Rosaceae) were diluted with ethanol (E) or water (W) and adsorbed onto a porous aluminometasilicate magnesium carrier (Neusilin (R) US2). The resulting wet blends were coated with colloidal silica, mixed with filler, disintegrant, lubricant and compressed. Tablets with incorporated liquid extract were dried by two different techniques: microwave drying (MW) and hot air drying (HA) at two different times. Blends and tablets were evaluated for physical properties and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). Partial least squares method (PLS) and ANOVA were used to assess tablet properties depending on the composition and parameters of the product. A longer drying time increased the hardness and density but reduced the porosity and loss of drying of the tablets. Maximum hardness was achieved by combining E with HA. Overall, drying process and the use of water solvent showed slightly negatively effect on AA of tablets, which is mainly influenced by the type of used extract.

Citovat

KURHAJEC, Slavomír, Klára KOSTELANSKÁ, Sylvie PAVLOKOVÁ, David VETCHÝ, Tomáš WOLASCHKA, Jan GAJDZIOK and Aleš FRANC. Stabilized antioxidative plant extracts formulated by liquisolid technique. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. AMSTERDAM: ELSEVIER, 2020, vol. 60, No 102022, p. 1-13. ISSN 1773-2247. Available from: https://dx.doi.org/10.1016/j.jddst.2020.102022.

@article{1745789,
   author = {Kurhajec, Slavomír and Kostelanská, Klára and Pavloková, Sylvie and Vetchý, David and Wolaschka, Tomáš and Gajdziok, Jan and Franc, Aleš},
   article_location = {AMSTERDAM},
   article_number = {102022},
   doi = {http://dx.doi.org/10.1016/j.jddst.2020.102022},
   keywords = {Neusilin (R); Antioxidant activity; Liquisolid system; Liquid plant extract; Drying process; Partial least squares},
   language = {eng},
   issn = {1773-2247},
   journal = {JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY},
   title = {Stabilized antioxidative plant extracts formulated by liquisolid technique},
   url = {https://www.sciencedirect.com/science/article/pii/S1773224720313113},
   volume = {60},
   year = {2020}
}

TY  - JOUR
ID  - 1745789
AU  - Kurhajec, Slavomír - Kostelanská, Klára - Pavloková, Sylvie - Vetchý, David - Wolaschka, Tomáš - Gajdziok, Jan - Franc, Aleš
PY  - 2020
TI  - Stabilized antioxidative plant extracts formulated by liquisolid technique
JF  - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
VL  - 60
IS  - 102022
SP  - 1-13
EP  - 1-13
PB  - ELSEVIER
SN  - 17732247
KW  - Neusilin (R)
KW  - Antioxidant activity
KW  - Liquisolid system
KW  - Liquid plant extract
KW  - Drying process
KW  - Partial least squares
UR  - https://www.sciencedirect.com/science/article/pii/S1773224720313113
N2  - Plant extracts with antioxidant activity are an important source of natural drugs. Usually are used as liquids, which are voluminous and often unstable. To overcome these obstacles, fast disintegrating tablets with high content of antioxidants were prepared by an innovative way of dried liquisolid system. The thickened extracts of Aronia melanocarpa, Crataegus leavigata and Rosa canina (Rosaceae) were diluted with ethanol (E) or water (W) and adsorbed onto a porous aluminometasilicate magnesium carrier (Neusilin (R) US2). The resulting wet blends were coated with colloidal silica, mixed with filler, disintegrant, lubricant and compressed. Tablets with incorporated liquid extract were dried by two different techniques: microwave drying (MW) and hot air drying (HA) at two different times. Blends and tablets were evaluated for physical properties and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). Partial least squares method (PLS) and ANOVA were used to assess tablet properties depending on the composition and parameters of the product. A longer drying time increased the hardness and density but reduced the porosity and loss of drying of the tablets. Maximum hardness was achieved by combining E with HA. Overall, drying process and the use of water solvent showed slightly negatively effect on AA of tablets, which is mainly influenced by the type of used extract.
ER  -

KURHAJEC, Slavomír, Klára KOSTELANSKÁ, Sylvie PAVLOKOVÁ, David VETCHÝ, Tomáš WOLASCHKA, Jan GAJDZIOK and Aleš FRANC. Stabilized antioxidative plant extracts formulated by liquisolid technique. \textit{JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY}. AMSTERDAM: ELSEVIER, 2020, vol.~60, No~102022, p.~1-13. ISSN~1773-2247. Available from: https://dx.doi.org/10.1016/j.jddst.2020.102022.

Detailed Information on Publication Record