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@article{1745789,
author = {Kurhajec, Slavomír and Kostelanská, Klára and Pavloková, Sylvie and Vetchý, David and Wolaschka, Tomáš and Gajdziok, Jan and Franc, Aleš},
article_location = {AMSTERDAM},
article_number = {102022},
doi = {http://dx.doi.org/10.1016/j.jddst.2020.102022},
keywords = {Neusilin (R); Antioxidant activity; Liquisolid system; Liquid plant extract; Drying process; Partial least squares},
language = {eng},
issn = {1773-2247},
journal = {JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY},
title = {Stabilized antioxidative plant extracts formulated by liquisolid technique},
url = {https://www.sciencedirect.com/science/article/pii/S1773224720313113},
volume = {60},
year = {2020}
}
TY - JOUR
ID - 1745789
AU - Kurhajec, Slavomír - Kostelanská, Klára - Pavloková, Sylvie - Vetchý, David - Wolaschka, Tomáš - Gajdziok, Jan - Franc, Aleš
PY - 2020
TI - Stabilized antioxidative plant extracts formulated by liquisolid technique
JF - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
VL - 60
IS - 102022
SP - 1-13
EP - 1-13
PB - ELSEVIER
SN - 17732247
KW - Neusilin (R)
KW - Antioxidant activity
KW - Liquisolid system
KW - Liquid plant extract
KW - Drying process
KW - Partial least squares
UR - https://www.sciencedirect.com/science/article/pii/S1773224720313113
N2 - Plant extracts with antioxidant activity are an important source of natural drugs. Usually are used as liquids, which are voluminous and often unstable. To overcome these obstacles, fast disintegrating tablets with high content of antioxidants were prepared by an innovative way of dried liquisolid system. The thickened extracts of Aronia melanocarpa, Crataegus leavigata and Rosa canina (Rosaceae) were diluted with ethanol (E) or water (W) and adsorbed onto a porous aluminometasilicate magnesium carrier (Neusilin (R) US2). The resulting wet blends were coated with colloidal silica, mixed with filler, disintegrant, lubricant and compressed. Tablets with incorporated liquid extract were dried by two different techniques: microwave drying (MW) and hot air drying (HA) at two different times. Blends and tablets were evaluated for physical properties and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). Partial least squares method (PLS) and ANOVA were used to assess tablet properties depending on the composition and parameters of the product. A longer drying time increased the hardness and density but reduced the porosity and loss of drying of the tablets. Maximum hardness was achieved by combining E with HA. Overall, drying process and the use of water solvent showed slightly negatively effect on AA of tablets, which is mainly influenced by the type of used extract.
ER -
KURHAJEC, Slavomír, Klára KOSTELANSKÁ, Sylvie PAVLOKOVÁ, David VETCHÝ, Tomáš WOLASCHKA, Jan GAJDZIOK and Aleš FRANC. Stabilized antioxidative plant extracts formulated by liquisolid technique. \textit{JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY}. AMSTERDAM: ELSEVIER, 2020, vol.~60, No~102022, p.~1-13. ISSN~1773-2247. Available from: https://dx.doi.org/10.1016/j.jddst.2020.102022.
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