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@article{1745798,
author = {Leláková, Veronika and BéraudandDufour, Sophie and Hošek, Jan and Šmejkal, Karel and Prachyawarakorn, Vilailak and Pailee, Phanruethai and Widmann, Catherine and Václavík, Jiří and Coppola, Thierry and Mazella, Jean and Blondeau, Nicolas and Heurteaux, Catherine},
article_location = {CLARE},
article_number = {263},
doi = {http://dx.doi.org/10.1016/j.jep.2020.113147},
keywords = {Natural stilbenoids; Neuroinflammation; Microglia; Monocytes; Prenyl},
language = {eng},
issn = {0378-8741},
journal = {JOURNAL OF ETHNOPHARMACOLOGY},
title = {Therapeutic potential of prenylated stilbenoid macasiamenene F through its anti-inflammatory and cytoprotective effects on LPS-challenged monocytes and microglia},
url = {https://www.sciencedirect.com/science/article/pii/S0378874120330294?via%3Dihub},
volume = {263},
year = {2020}
}
TY - JOUR
ID - 1745798
AU - Leláková, Veronika - Béraud-Dufour, Sophie - Hošek, Jan - Šmejkal, Karel - Prachyawarakorn, Vilailak - Pailee, Phanruethai - Widmann, Catherine - Václavík, Jiří - Coppola, Thierry - Mazella, Jean - Blondeau, Nicolas - Heurteaux, Catherine
PY - 2020
TI - Therapeutic potential of prenylated stilbenoid macasiamenene F through its anti-inflammatory and cytoprotective effects on LPS-challenged monocytes and microglia
JF - JOURNAL OF ETHNOPHARMACOLOGY
VL - 263
IS - 263
SP - 1-14
EP - 1-14
PB - ELSEVIER IRELAND LTD
SN - 03788741
KW - Natural stilbenoids
KW - Neuroinflammation
KW - Microglia
KW - Monocytes
KW - Prenyl
UR - https://www.sciencedirect.com/science/article/pii/S0378874120330294?via%3Dihub
N2 - Ethnopharmacological relevance: Macaranga Thou. (Euphorbiaceae) is a large genus that comprises over 300 species distributed between Western Africa and the islands of the South Pacific. Plants of this genus have a long-standing history of use in traditional medicine for different purposes, including the treatment of inflammation. Fresh and dried leaves of certain Macaranga species (e.g. M. tanarius (L.) Müll.Arg.), have been used to treat cuts, bruises, boils, swellings, sores and covering of wounds in general. Several reports described Macaranga spp. being a rich source of polyphenols, such as prenylated stilbenoids and flavonoids, mostly responsible for its biological activity. Similarly, an abundant content of prenylated stilbenes was also described in M. siamensis S.J.Davies, species recently identified (2001) in Thailand. While the respective biological activity of the prenylated stilbenes from M. siamensis was poorly investigated to date, our recent study pointed out the interest as the natural source of several novel anti-inflammatory stilbenoids isolated from this species.
ER -
LELÁKOVÁ, Veronika, Sophie BÉRAUD-DUFOUR, Jan HOŠEK, Karel ŠMEJKAL, Vilailak PRACHYAWARAKORN, Phanruethai PAILEE, Catherine WIDMANN, Jiří VÁCLAVÍK, Thierry COPPOLA, Jean MAZELLA, Nicolas BLONDEAU a Catherine HEURTEAUX. Therapeutic potential of prenylated stilbenoid macasiamenene F through its anti-inflammatory and cytoprotective effects on LPS-challenged monocytes and microglia. \textit{JOURNAL OF ETHNOPHARMACOLOGY}. CLARE: ELSEVIER IRELAND LTD, 2020, roč.~263, č.~263, s.~1-14. ISSN~0378-8741. Dostupné z: https://dx.doi.org/10.1016/j.jep.2020.113147.
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