| ROTREKL, Dominik, B. DEVRIENDT, E. COX, L. KAVANOVA, M. FALDYNA, P. SALAMUNOVA, Zuzana BAĎO, V. PROKOPEC, F. STEPANEK, J. HANUS and J. HOSEK. Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model. International Journal of Pharmaceutics. AMSTERDAM: ELSEVIER SCIENCE BV, 2020, vol. 582, No 119318, p. 1-10. ISSN 0378-5173. Available from: https://dx.doi.org/10.1016/j.ijpharm.2020.119318. |
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@article{1745919,
author = {Rotrekl, Dominik and Devriendt, B. and Cox, E. and Kavanova, L. and Faldyna, M. and Salamunova, P. and Baďo, Zuzana and Prokopec, V. and Stepanek, F. and Hanus, J. and Hosek, J.},
article_location = {AMSTERDAM},
article_number = {119318},
doi = {http://dx.doi.org/10.1016/j.ijpharm.2020.119318},
keywords = {Glucan particles; Immunomodulatory effect; Inflammation; Blood immune cells; Curcumin; Diplacone},
language = {eng},
issn = {0378-5173},
journal = {International Journal of Pharmaceutics},
title = {Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model},
url = {https://www.sciencedirect.com/science/article/pii/S0378517320303021},
volume = {582},
year = {2020}
}
TY - JOUR
ID - 1745919
AU - Rotrekl, Dominik - Devriendt, B. - Cox, E. - Kavanova, L. - Faldyna, M. - Salamunova, P. - Baďo, Zuzana - Prokopec, V. - Stepanek, F. - Hanus, J. - Hosek, J.
PY - 2020
TI - Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model
JF - International Journal of Pharmaceutics
VL - 582
IS - 119318
SP - 1-10
EP - 1-10
PB - ELSEVIER SCIENCE BV
SN - 03785173
KW - Glucan particles
KW - Immunomodulatory effect
KW - Inflammation
KW - Blood immune cells
KW - Curcumin
KW - Diplacone
UR - https://www.sciencedirect.com/science/article/pii/S0378517320303021
N2 - Natural compounds offer a wide spectrum of potential active substances, but often they have a poor bioavailability. To increase the bioavailability and bioactivity of the natural anti-inflammatory molecules curcumin and diplacone, we used glucan particles (GPs), hollow shells from Saccharomyces cerevisiae composed mainly of beta-1,3-D-glucan. Their indigestibility and relative stability in the gut combined with their immunomodulatory effects makes them promising carriers for such compounds. This study aimed to determine how curcumin and diplacone, either alone or incorporated in GPs, affect the immunomodulatory activity of the latter by assessing the respiratory burst response and the secretion of pro-inflammatory cytokines by primary porcine innate immune cells. Incorporating curcumin and diplacone into GPs by controlled evaporation of the organic solvent substantially reduced the respiratory burst response mediated by GPs. Incorporated curcumin in GPs also reduced GPs mediated secretion of IL-1 beta and TNF-alpha by innate immune cells. The obtained results indicate a potentially beneficial effect of the incorporation of curcumin or diplacone into GPs against inflammation.
ER -
ROTREKL, Dominik, B. DEVRIENDT, E. COX, L. KAVANOVA, M. FALDYNA, P. SALAMUNOVA, Zuzana BAĎO, V. PROKOPEC, F. STEPANEK, J. HANUS and J. HOSEK. Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model. \textit{International Journal of Pharmaceutics}. AMSTERDAM: ELSEVIER SCIENCE BV, 2020, vol.~582, No~119318, p.~1-10. ISSN~0378-5173. Available from: https://dx.doi.org/10.1016/j.ijpharm.2020.119318.
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