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@article{1749076,
author = {Hortová Kohoutková, Marcela and Tidu, Federico and De Zuani, Marco and Šrámek, Vladimír and Helán, Martin and Fric, Jan},
article_location = {Philadelphia},
article_number = {5},
doi = {http://dx.doi.org/10.1097/SHK.0000000000001541},
keywords = {Monocyte; phagocytosis; sepsis; signaling},
language = {eng},
issn = {1073-2322},
journal = {Shock},
title = {PHAGOCYTOSIS-INFLAMMATION CROSSTALK IN SEPSIS: NEW AVENUES FOR THERAPEUTIC INTERVENTION},
url = {https://journals.lww.com/shockjournal/Fulltext/2020/11000/Phagocytosis_Inflammation_Crosstalk_in_Sepsis__New.4.aspx},
volume = {54},
year = {2020}
}
TY - JOUR
ID - 1749076
AU - Hortová Kohoutková, Marcela - Tidu, Federico - De Zuani, Marco - Šrámek, Vladimír - Helán, Martin - Fric, Jan
PY - 2020
TI - PHAGOCYTOSIS-INFLAMMATION CROSSTALK IN SEPSIS: NEW AVENUES FOR THERAPEUTIC INTERVENTION
JF - Shock
VL - 54
IS - 5
SP - 606-614
EP - 606-614
PB - Lippincott Williams & Wilkins
SN - 10732322
KW - Monocyte
KW - phagocytosis
KW - sepsis
KW - signaling
UR - https://journals.lww.com/shockjournal/Fulltext/2020/11000/Phagocytosis_Inflammation_Crosstalk_in_Sepsis__New.4.aspx
N2 - Phagocytosis is a complex process by which cells within most organ systems remove pathogens and cell debris. Phagocytosis is usually followed by inflammatory pathway activation, which promotes pathogen elimination and inhibits pathogen growth. Delayed pathogen elimination is the first step in sepsis development and a key factor in sepsis resolution. Phagocytosis thus has an important role during sepsis and likely contributes to all of its clinical stages. However, only a few studies have specifically explored and characterized phagocytic activity during sepsis. Here, we describe the phagocytic processes that occur as part of the immune response preceding sepsis onset and identify the elements of phagocytosis that might constitute a predictive marker of sepsis outcomes. First, we detail the key features of phagocytosis, including the main receptors and signaling hallmarks associated with different phagocytic processes. We then discuss how the initial events of phagosome formation and cytoskeletal remodeling might be associated with known sepsis features, such as a cytokine-driven hyperinflammatory response and immunosuppression. Finally, we highlight the unresolved mechanisms of sepsis development and progression and the need for cross-disciplinary approaches to link the clinical complexity of the disease with basic cellular and molecular mechanisms.
ER -
HORTOVÁ KOHOUTKOVÁ, Marcela, Federico TIDU, Marco DE ZUANI, Vladimír ŠRÁMEK, Martin HELÁN and Jan FRIC. PHAGOCYTOSIS-INFLAMMATION CROSSTALK IN SEPSIS: NEW AVENUES FOR THERAPEUTIC INTERVENTION. \textit{Shock}. Philadelphia: Lippincott Williams \&{} Wilkins, 2020, vol.~54, No~5, p.~606-614. ISSN~1073-2322. Available from: https://dx.doi.org/10.1097/SHK.0000000000001541.
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