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@article{1751036,
author = {Grybchuk, Danyil and Macedo, D.H. and Kleschenko, Y. and Kraeva, N. and Lukashev, A.N. and Bates, P.A. and Kulich, P. and Lestinova, T. and Volf, P. and Kostygov, A.Y. and Yurchenko, V.},
article_location = {Basel, Switzerland},
article_number = {2},
doi = {http://dx.doi.org/10.3390/v12020168},
keywords = {Bunyavirales; Leishmania martiniquensis; leishbunyavirus},
language = {eng},
issn = {1999-4915},
journal = {Viruses-Basel},
title = {The First Non-LRV RNA Virus in Leishmania},
url = {https://www.mdpi.com/1999-4915/12/2/168},
volume = {12},
year = {2020}
}
TY - JOUR
ID - 1751036
AU - Grybchuk, Danyil - Macedo, D.H. - Kleschenko, Y. - Kraeva, N. - Lukashev, A.N. - Bates, P.A. - Kulich, P. - Lestinova, T. - Volf, P. - Kostygov, A.Y. - Yurchenko, V.
PY - 2020
TI - The First Non-LRV RNA Virus in Leishmania
JF - Viruses-Basel
VL - 12
IS - 2
SP - 168
EP - 168
PB - MDPI AG
SN - 19994915
KW - Bunyavirales
KW - Leishmania martiniquensis
KW - leishbunyavirus
UR - https://www.mdpi.com/1999-4915/12/2/168
N2 - In this work, we describe the first Leishmania-infecting leishbunyavirus-the first virus other than Leishmania RNA virus (LRV) found in trypanosomatid parasites. Its host is Leishmania martiniquensis, a human pathogen causing infections with a wide range of manifestations from asymptomatic to severe visceral disease. This virus (LmarLBV1) possesses many characteristic features of leishbunyaviruses, such as tripartite organization of its RNA genome, with ORFs encoding RNA-dependent RNA polymerase, surface glycoprotein, and nucleoprotein on L, M, and S segments, respectively. Our phylogenetic analyses suggest that LmarLBV1 originated from leishbunyaviruses of monoxenous trypanosomatids and, probably, is a result of genomic re-assortment. The LmarLBV1 facilitates parasites' infectivity in vitro in primary murine macrophages model. The discovery of a virus in L. martiniquensis poses the question of whether it influences pathogenicity of this parasite in vivo, similarly to the LRV in other Leishmania species.
ER -
GRYBCHUK, Danyil, D.H. MACEDO, Y. KLESCHENKO, N. KRAEVA, A.N. LUKASHEV, P.A. BATES, P. KULICH, T. LESTINOVA, P. VOLF, A.Y. KOSTYGOV and V. YURCHENKO. The First Non-LRV RNA Virus in Leishmania. \textit{Viruses-Basel}. Basel, Switzerland: MDPI AG, 2020, vol.~12, No~2, p.~168-184. ISSN~1999-4915. Available from: https://dx.doi.org/10.3390/v12020168.
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