Virion structures and genome delivery of honeybee viruses

PROCHÁZKOVÁ, Michaela, Karel ŠKUBNÍK, Tibor FÜZIK, Liya MUKHAMEDOVA, A. PRIDAL and Pavel PLEVKA. Virion structures and genome delivery of honeybee viruses. CURRENT OPINION IN VIROLOGY. OXFORD: ELSEVIER SCI LTD, 2020, vol. 45, DEC, p. 17-24. ISSN 1879-6257. Available from: https://dx.doi.org/10.1016/j.coviro.2020.06.007.

Basic information

• Original name: Virion structures and genome delivery of honeybee viruses
• Authors: PROCHÁZKOVÁ, Michaela (203 Czech Republic, belonging to the institution), Karel ŠKUBNÍK (203 Czech Republic, belonging to the institution), Tibor FÜZIK (703 Slovakia, belonging to the institution), Liya MUKHAMEDOVA (643 Russian Federation, belonging to the institution), A. PRIDAL and Pavel PLEVKA (203 Czech Republic, guarantor, belonging to the institution).
• Edition: CURRENT OPINION IN VIROLOGY, OXFORD, ELSEVIER SCI LTD, 2020, 1879-6257.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10607 Virology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 7.090
• RIV identification code: RIV/00216224:14740/20:00114765
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1016/j.coviro.2020.06.007
• UT WoS: 000600758100004
• Keywords in English: DEFORMED WING VIRUS; BEE PARALYSIS VIRUS; PICORNA-LIKE VIRUS; APIS-MELLIFERA L.; IN-VITRO; IDENTIFICATION; DECLINES; TRANSMISSION; PARTICLES; SACBROOD
• Tags: rivok
• Tags: International impact, Reviewed

Abstract

The western honeybee is the primary pollinator of numerous food crops. Furthermore, honeybees are essential for ecosystem stability by sustaining the diversity and abundance of wild flowering plants. However, the worldwide population of honeybees is under pressure from environmental stress and pathogens. Viruses from the families Iflaviridae and Dicistroviridae, together with their vector, the parasitic mite Varroa destructor, are the major threat to the world's honeybees. Dicistroviruses and iflaviruses have capsids with icosahedral symmetries. Acidic pH triggers the genome release of both dicistroviruses and iflaviruses. The capsids of iflaviruses expand, whereas those of dicistroviruses remain compact until the genome release. Furthermore, dicistroviruses use inner capsid proteins, whereas iflaviruses employ protruding domains or minor capsid proteins from the virion surface to penetrate membranes and deliver their genomes into the cell cytoplasm. The structural characterization of the infection process opens up possibilities for the development of antiviral compounds.

Links

• GX19-25982X, research and development project: Name: Analýza replikace enterovirů s využitím elektronové mikroskopie

Investor: Czech Science Foundation

• LQ1601, research and development project: Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

• 3041, interní kód MU: Name: Structural studies of human and animal pathogens from the order Picornavirales

Investor: EMBO (European Molecular Biology Organization)