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@article{1752440,
author = {Hodkovicova, N. and Enevova, V. and Cahova, J. and Blahova, J. and Siroka, Z. and Plhalova, L. and Doubkova, V. and Marsalek, P. and Franc, Aleš and Fiorino, E. and Faggio, C. and Tichy, F. and Faldyna, M. and Svobodova, Z.},
article_location = {Praha},
article_number = {4},
doi = {http://dx.doi.org/10.33549/physiolres.934608},
keywords = {Hematology; Biochemistry; Htology; Lipid peroxidation; Oncorhynchus mykiss},
language = {eng},
issn = {0862-8408},
journal = {Physiological research},
title = {Could the Musk Compound Tonalide Affect Physiological Functions and Act as an Endocrine Disruptor in Rainbow Trout?},
url = {https://www.biomed.cas.cz/physiolres/pdf/2020/69_S595.pdf},
volume = {69},
year = {2020}
}
TY - JOUR
ID - 1752440
AU - Hodkovicova, N. - Enevova, V. - Cahova, J. - Blahova, J. - Siroka, Z. - Plhalova, L. - Doubkova, V. - Marsalek, P. - Franc, Aleš - Fiorino, E. - Faggio, C. - Tichy, F. - Faldyna, M. - Svobodova, Z.
PY - 2020
TI - Could the Musk Compound Tonalide Affect Physiological Functions and Act as an Endocrine Disruptor in Rainbow Trout?
JF - Physiological research
VL - 69
IS - 4
SP - "S595"-"S606"
EP - "S595"-"S606"
PB - Fyziologický ústav AV ČR
SN - 08628408
KW - Hematology
KW - Biochemistry
KW - Htology
KW - Lipid peroxidation
KW - Oncorhynchus mykiss
UR - https://www.biomed.cas.cz/physiolres/pdf/2020/69_S595.pdf
N2 - In the present study, the effect of polycyclic musk compound tonalide (AHTN) in two concentrations was studied in male rainbow trout (Oncorhynchus mykiss, Walbaum 1792). A feeding trial was conducted with AHTN incorporated into feed granules. One concentration was environmentally relevant (854 mu g/kg); the second one was 10x higher (8699 mu g/kg). The fish were fed twice a day with the amount of feed at 1 % of their body weight. After an acclimatization period, the experimental phase in duration of six weeks followed. At the end of the experiment, fish were sampled and the biometrical data were recorded. Subsequently, hematological and biochemical tests, histopathological examination, analysis of oxidative stress markers and evaluation of endocrine disruption using plasma vitellogenin were performed. In conclusion, an increase of hematocrit for both AHTN concentrations was found, but no significant changes were observed in biochemical profile. Moreover, AHTN caused lipid peroxidation in caudal kidney tissue, which was confirmed by histopathological images. The long-lasting AHTN exposure could thus be harmful for maintaining homeostasis in the rainbow trout organism. However, the vitellogenin concentration seemed not to be affected by AHTN.
ER -
HODKOVICOVA, N., V. ENEVOVA, J. CAHOVA, J. BLAHOVA, Z. SIROKA, L. PLHALOVA, V. DOUBKOVA, P. MARSALEK, Aleš FRANC, E. FIORINO, C. FAGGIO, F. TICHY, M. FALDYNA and Z. SVOBODOVA. Could the Musk Compound Tonalide Affect Physiological Functions and Act as an Endocrine Disruptor in Rainbow Trout? \textit{Physiological research}. Praha: Fyziologický ústav AV ČR, 2020, vol.~69, No~4, p.~''S595''-''S606'', 12 pp. ISSN~0862-8408. Available from: https://dx.doi.org/10.33549/physiolres.934608.
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