High syphilis seropositivity in European brown hares (Lepus
europaeus), Lower Saxony, Germany

J 2020

High syphilis seropositivity in European brown hares (Lepus europaeus), Lower Saxony, Germany

HISGEN, L., L. ABEL, L. K. HALLMAIER-WACKER, S. LUEERT, U. SIEBERT et. al.

Basic information

Original name

High syphilis seropositivity in European brown hares (Lepus europaeus), Lower Saxony, Germany

Authors

HISGEN, L., L. ABEL, L. K. HALLMAIER-WACKER, S. LUEERT, U. SIEBERT, M. FAEHNDRICH, E. STRAUSS, U. VOIGT, Markéta NOVÁKOVÁ (203 Czech Republic, belonging to the institution), David ŠMAJS (203 Czech Republic, belonging to the institution) and S. KNAUF

Edition

Transboundary and Emerging Diseases, Hoboken, Wiley-Blackwell, 2020, 1865-1674

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.005

RIV identification code

RIV/00216224:14110/20:00114768

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/tbed.13551

UT WoS

000524336300001

Keywords in English

lagomorpha; Lepus europaeus; rabbit; serology; spirochaete; Treponema paraluisleporidarum

Abstract

V originále

The lagomorph-infecting Treponema paraluisleporidarum is a close relative of the human syphilis-bacterium Treponema pallidum. There is a paucity of information on the epidemiology of hare syphilis and its relationship to the rabbit- and human-infecting treponemes that cause syphilis. In our study, we tested 734 serum samples from European brown hares (Lepus europaeus) collected between 2007 and 2019 in the federal state of Lower Saxony, Germany, for the presence of antibodies against T. paraluisleporidarum. Since T. paraluisleporidarum cross-reacts with T. pallidum antigen, we used a commercially available T. pallidum-particle agglutination (TP-PA) assay to test for the presence of antibodies. A high seropositivity (n = 405/734) was detected. An additional 233 serum samples were retested using a fluorescent treponemal antibody absorption test to confirm the results of the TP-PA assay. Our results show that infection is widespread in Lower Saxony and suggest a horizontal (sexual) transmission mode since adult hares show significantly higher seropositivity than subadults (odds ratio: 0.03 [95% CI 0.02-0.05], p < .0001). No difference was detected based on gender (odds ratio: 0.79 [95% Cl 0.58-1.07], p = .1283). Further studies are warranted to genetically characterize the T. paraluisleporidarum strains that infect wild hares.

Links

GC18-23521J, research and development project

Name: Treponematózy u zástupců řádu zajícovci: genetická diverzita treponem a příbuznost s lidským patogenem T. pallidum

Investor: Czech Science Foundation

Citovat

HISGEN, L., L. ABEL, L. K. HALLMAIER-WACKER, S. LUEERT, U. SIEBERT, M. FAEHNDRICH, E. STRAUSS, U. VOIGT, Markéta NOVÁKOVÁ, David ŠMAJS and S. KNAUF. High syphilis seropositivity in European brown hares (Lepus europaeus), Lower Saxony, Germany. Transboundary and Emerging Diseases. Hoboken: Wiley-Blackwell, 2020, vol. 67, No 5, p. 2240-2244. ISSN 1865-1674. Available from: https://dx.doi.org/10.1111/tbed.13551.

@article{1753389,
   author = {Hisgen, L. and Abel, L. and HallmaierandWacker, L. K. and Lueert, S. and Siebert, U. and Faehndrich, M. and Strauss, E. and Voigt, U. and Nováková, Markéta and Šmajs, David and Knauf, S.},
   article_location = {Hoboken},
   article_number = {5},
   doi = {http://dx.doi.org/10.1111/tbed.13551},
   keywords = {lagomorpha; Lepus europaeus; rabbit; serology; spirochaete; Treponema paraluisleporidarum},
   language = {eng},
   issn = {1865-1674},
   journal = {Transboundary and Emerging Diseases},
   title = {High syphilis seropositivity in European brown hares (Lepus europaeus), Lower Saxony, Germany},
   url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tbed.13551},
   volume = {67},
   year = {2020}
}

TY  - JOUR
ID  - 1753389
AU  - Hisgen, L. - Abel, L. - Hallmaier-Wacker, L. K. - Lueert, S. - Siebert, U. - Faehndrich, M. - Strauss, E. - Voigt, U. - Nováková, Markéta - Šmajs, David - Knauf, S.
PY  - 2020
TI  - High syphilis seropositivity in European brown hares (Lepus europaeus), Lower Saxony, Germany
JF  - Transboundary and Emerging Diseases
VL  - 67
IS  - 5
SP  - 2240-2244
EP  - 2240-2244
PB  - Wiley-Blackwell
SN  - 18651674
KW  - lagomorpha
KW  - Lepus europaeus
KW  - rabbit
KW  - serology
KW  - spirochaete
KW  - Treponema paraluisleporidarum
UR  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tbed.13551
N2  - The lagomorph-infecting Treponema paraluisleporidarum is a close relative of the human syphilis-bacterium Treponema pallidum. There is a paucity of information on the epidemiology of hare syphilis and its relationship to the rabbit- and human-infecting treponemes that cause syphilis. In our study, we tested 734 serum samples from European brown hares (Lepus europaeus) collected between 2007 and 2019 in the federal state of Lower Saxony, Germany, for the presence of antibodies against T. paraluisleporidarum. Since T. paraluisleporidarum cross-reacts with T. pallidum antigen, we used a commercially available T. pallidum-particle agglutination (TP-PA) assay to test for the presence of antibodies. A high seropositivity (n = 405/734) was detected. An additional 233 serum samples were retested using a fluorescent treponemal antibody absorption test to confirm the results of the TP-PA assay. Our results show that infection is widespread in Lower Saxony and suggest a horizontal (sexual) transmission mode since adult hares show significantly higher seropositivity than subadults (odds ratio: 0.03 [95% CI 0.02-0.05], p < .0001). No difference was detected based on gender (odds ratio: 0.79 [95% Cl 0.58-1.07], p = .1283). Further studies are warranted to genetically characterize the T. paraluisleporidarum strains that infect wild hares.
ER  -

HISGEN, L., L. ABEL, L. K. HALLMAIER-WACKER, S. LUEERT, U. SIEBERT, M. FAEHNDRICH, E. STRAUSS, U. VOIGT, Markéta NOVÁKOVÁ, David ŠMAJS and S. KNAUF. High syphilis seropositivity in European brown hares (Lepus europaeus), Lower Saxony, Germany. \textit{Transboundary and Emerging Diseases}. Hoboken: Wiley-Blackwell, 2020, vol.~67, No~5, p.~2240-2244. ISSN~1865-1674. Available from: https://dx.doi.org/10.1111/tbed.13551.

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