Letter to the Editor: Significant mutation enrichment in inverted repeat sites of new SARS-CoV-2 strains
Authors
BARTAS, Martin, Pratik GOSWAMI (356 India, belonging to the institution), Matej LEXA (703 Slovakia, belonging to the institution), Jiří ČERVEŇ, Adriana VOLNÁ, Miroslav FOJTA, Vaclav BRAZDA and Petr PEČINKA
Edition
Briefings in Bioinformatics, Oxford University Press, 2021, 1467-5463
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10603 Genetics and heredity
Country of publisher
United Kingdom of Great Britain and Northern Ireland
In a recently published paper, we have found that SARS-CoV-2 hot-spot mutations are significantly associated with inverted repeat loci and CG dinucleotides (Goswami, Bartas et al., 2020). However, fast-spreading strains with new mutations (so-called mink farm mutations, England mutations, and Japan mutations) have been recently described. We used the new datasets to check the positioning of mutation sites in genomes of the new SARS-CoV-2 strains. Using an open-access Palindrome analyzer tool we found mutations in these new strains to be significantly enriched in inverted repeat loci.