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@article{1755479,
author = {Jouybari, L. and Kiani, F. and Islami, F. and Sanagoo, A. and Sayehmiri, F. and Hosnedlova, B. and Dosa, M. D. and Kizek, René and Chirumbolo, S. and Bjorklund, G.},
article_location = {Sharjah},
article_number = {37},
doi = {http://dx.doi.org/10.2174/0929867326666190918120209},
keywords = {Copper; breast cancer; women; blood; breast tissue; hair analysis},
language = {eng},
issn = {0929-8673},
journal = {Current Medicinal Chemistry},
title = {Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis},
url = {https://pubmed.ncbi.nlm.nih.gov/31533596/},
volume = {27},
year = {2020}
}
TY - JOUR
ID - 1755479
AU - Jouybari, L. - Kiani, F. - Islami, F. - Sanagoo, A. - Sayehmiri, F. - Hosnedlova, B. - Dosa, M. D. - Kizek, René - Chirumbolo, S. - Bjorklund, G.
PY - 2020
TI - Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis
JF - Current Medicinal Chemistry
VL - 27
IS - 37
SP - 6373-6383
EP - 6373-6383
PB - Betham Science Publishers
SN - 09298673
KW - Copper
KW - breast cancer
KW - women
KW - blood
KW - breast tissue
KW - hair analysis
UR - https://pubmed.ncbi.nlm.nih.gov/31533596/
N2 - Breast cancer is the most common neoplasm, comprising 16% of all women's cancers worldwide. Research of Copper (Cu) concentrations in various body specimens have suggested an association between Cu levels and breast cancer risks. This systematic review and meta-analysis summarize the results of published studies and examine this association. We searched the databases PubMed, Scopus, Web of Science, and Google Scholar and the reference lists of relevant publications. The Standardized Mean Differences (SMDs) between Cu levels in cancer cases and controls and corresponding Confidence Intervals (CIs), as well as I-2 statistics, were calculated to examine heterogeneity. Following the specimens used in the original studies, the Cu concentrations were examined in three subgroups: serum or plasma, breast tissue, and scalp hair. We identified 1711 relevant studies published from 1984 to 2017. There was no statistically significant difference between breast cancer cases and controls for Cu levels assayed in any studied specimen; the SMD (95% CI) was -0.01 (-1.06 - 1.03; P = 0.98) for blood or serum, 0.51 (-0.70 - 1.73; P = 0.41) for breast tissue, and -0.88 (-3.42 - 1.65; P = 0.50) for hair samples. However, the heterogeneity between studies was very high (P < 0.001) in all subgroups. We did not find evidence for publication bias (P = 0.91). The results of this meta-analysis do not support an association between Cu levels and breast cancer. However, due to high heterogeneity in the results of original studies, this conclusion needs to be confirmed by well-designed prospective studies.
ER -
JOUYBARI, L., F. KIANI, F. ISLAMI, A. SANAGOO, F. SAYEHMIRI, B. HOSNEDLOVA, M. D. DOSA, René KIZEK, S. CHIRUMBOLO and G. BJORKLUND. Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis. \textit{Current Medicinal Chemistry}. Sharjah: Betham Science Publishers, 2020, vol.~27, No~37, p.~6373-6383. ISSN~0929-8673. Available from: https://dx.doi.org/10.2174/0929867326666190918120209.
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