BJORKLUND, G., N. A. MEGUID, M. A. EL-BANA, A. A. TINKOV, K. SAAD, M. DADAR, M. HEMIMI, A. V. SKALNY, B. HOSNEDLOVA, René KIZEK, J. OSREDKAR, M. A. URBINA, T. FABJAN, A. A. EL-HOUFEY, J. KALUZNA-CZAPLINSKA, P. GATAREK and S. CHIRUMBOLO. Oxidative Stress in Autism Spectrum Disorder. Molecular Neurobiology. New York: Springer, 2020, vol. 57, No 5, p. 2314-2332. ISSN 0893-7648. Available from: https://dx.doi.org/10.1007/s12035-019-01742-2.
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Basic information
Original name Oxidative Stress in Autism Spectrum Disorder
Authors BJORKLUND, G. (guarantor), N. A. MEGUID, M. A. EL-BANA, A. A. TINKOV, K. SAAD, M. DADAR, M. HEMIMI, A. V. SKALNY, B. HOSNEDLOVA, René KIZEK (203 Czech Republic, belonging to the institution), J. OSREDKAR, M. A. URBINA, T. FABJAN, A. A. EL-HOUFEY, J. KALUZNA-CZAPLINSKA, P. GATAREK and S. CHIRUMBOLO.
Edition Molecular Neurobiology, New York, Springer, 2020, 0893-7648.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 5.590
RIV identification code RIV/00216224:14160/20:00118455
Organization unit Faculty of Pharmacy
Doi http://dx.doi.org/10.1007/s12035-019-01742-2
UT WoS 000518149900001
Keywords in English Autism; Oxidative stress; Reactive oxygen species; Inflammation; ASD
Tags rivok, ÚFTo
Tags International impact, Reviewed
Changed by Changed by: Mgr. Hana Hurtová, učo 244985. Changed: 25/3/2021 18:48.
Abstract
According to the United States Centers for Disease Control and Prevention (CDC), as of July 11, 2016, the reported average incidence of children diagnosed with an autism spectrum disorder (ASD) was 1 in 68 (1.46%) among 8-year-old children born in 2004 and living within the 11 monitoring sites' surveillance areas in the United States of America (USA) in 2012. ASD is a multifaceted neurodevelopmental disorder that is also considered a hidden disability, as, for the most part; there are no apparent morphological differences between children with ASD and typically developing children. ASD is diagnosed based upon a triad of features including impairment in socialization, impairment in language, and repetitive and stereotypic behaviors. The increasing incidence of ASD in the pediatric population and the lack of successful curative therapies make ASD one of the most challenging disorders for medicine. ASD neurobiology is thought to be associated with oxidative stress, as shown by increased levels of reactive oxygen species and increased lipid peroxidation, as well as an increase in other indicators of oxidative stress. Children with ASD diagnosis are considered more vulnerable to oxidative stress because of their imbalance in intracellular and extracellular glutathione levels and decreased glutathione reserve capacity. Several studies have suggested that the redox imbalance and oxidative stress are integral parts of ASD pathophysiology. As such, early assessment and treatment of antioxidant status may result in a better prognosis as it could decrease the oxidative stress in the brain before it can induce more irreversible brain damage. In this review, many aspects of the role of oxidative stress in ASD are discussed, taking into account that the process of oxidative stress may be a target for therapeutic interventions.
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