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@proceedings{1756276,
author = {Pecl, Jakub and Jabandžiev, Petr and Vaculová, Jitka and Karásková, Eva and Šuláková, Astrid and Ťoukálková, Lenka and Zimen, Martin},
booktitle = {ESGE Days 2021},
doi = {http://dx.doi.org/10.1055/s-0041-1724949},
keywords = {eosinophilic esophagitis – children – pediatrics – endoscopy},
language = {eng},
title = {10 years of experience with eosinophilic esophagitis in five Czech pediatric endoscopy centers},
year = {2021}
}
TY - CONF
ID - 1756276
AU - Pecl, Jakub - Jabandžiev, Petr - Vaculová, Jitka - Karásková, Eva - Šuláková, Astrid - Ťoukálková, Lenka - Zimen, Martin
PY - 2021
TI - 10 years of experience with eosinophilic esophagitis in five Czech pediatric endoscopy centers
KW - eosinophilic esophagitis – children – pediatrics – endoscopy
N2 - Background: Eosinophilic esophagitis (EoE) is a chronic, progressive inflammatory disease of the esophagus characterized by local eosinophilic infiltration accompanied by symptoms of esophageal dysfunction. The aim of this study was to characterize features of EoE diagnosed regionally and to describe local strategies for its treatment. Methods: The observational survey retrospectively analyzed a data set of child patients with histologically proven EoE from five pediatric endoscopy centers. This analysis focused on describing their general situation (age, gender, symptoms) and also aimed to investigate any possible linkage between age and symptoms or length of diagnosis period. Demographic features; clinical symptoms; laboratory, endoscopic, and histopathological findings; and chosen treatment of patients were recorded and analyzed. Results: From January 2010 to September 2020, 33 new cases of EoE were reported. Strong association of EoE with male sex is consistent with the results from formerly published studies (81.8%). The median age of symptom onset was 7 years, while the median age for diagnosis was almost 13 years. The most common symptoms were reflux symptoms in general (39.4%), followed by vomiting (36.4%), and dysphagia (33.3%). Examination for sensitization to food allergens was performed on 23 (69.7%) patients with diagnosed EoE. Out of these, 17 (51.5% of all cases) were found to be sensitive to some allergens. Most of this subgroup (and 48.5% of all cases) were examined by specific IgE testing, and just 2 (6.1% of all cases) patients were tested only by skin prick tests. Another allergic comorbidity was present in 75.8% of patients, and the most common of these were bronchial asthma and allergic rhinoconjunctivitis (45.5% and 42.2%, respectively). More than two-thirds of patients (69.7%) had abnormal macroscopic findings during diagnostic endoscopy, and the most common were longitudinal furrows and white exudates. The most common initial modality of treatment was to use proton-pump inhibitors (PPI; 93.9%), followed by food elimination (75.8%) and then by corticosteroid administration (63.6%). The vast majority of patients treated with corticosteroids received a topical preparation (90.9%). Conclusion: This is the first retrospective study on pediatric patients with EoE in the Czech Republic. We found similar features of EoE as reported in formerly published works elsewhere. Collecting long-term prospective observational data in a national EoE register of patients in the Czech Republic would significantly improve our knowledge of this disease.
ER -
PECL, Jakub, Petr JABANDŽIEV, Jitka VACULOVÁ, Eva KARÁSKOVÁ, Astrid ŠULÁKOVÁ, Lenka ŤOUKÁLKOVÁ a Martin ZIMEN. 10 years of experience with eosinophilic esophagitis in five Czech pediatric endoscopy centers. In \textit{ESGE Days 2021}. 2021. Dostupné z: https://dx.doi.org/10.1055/s-0041-1724949.
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