NBQX attenuates relapse of nicotine seeking but not nicotine and methamphetamine self-administration in rats

RUDÁ, Jana, Petra AMCHOVÁ, Filip ŠIŠKA and Yousef TIZABI. NBQX attenuates relapse of nicotine seeking but not nicotine and methamphetamine self-administration in rats. The World Journal of Biological Psychiatry. Abingdon: TAYLOR & FRANCIS, 2021, vol. 22, No 10, p. 733-743. ISSN 1562-2975. Available from: https://dx.doi.org/10.1080/15622975.2021.1907714.

Basic information

• Original name: NBQX attenuates relapse of nicotine seeking but not nicotine and methamphetamine self-administration in rats
• Name in Czech: NBQX snižuje relaps vyhledávání nikotinu, ale ne operantní příjem nikotinu či metamfetaminu u potkana
• Authors: RUDÁ, Jana (203 Czech Republic, guarantor, belonging to the institution), Petra AMCHOVÁ (203 Czech Republic, belonging to the institution), Filip ŠIŠKA (703 Slovakia, belonging to the institution) and Yousef TIZABI (840 United States of America).
• Edition: The World Journal of Biological Psychiatry, Abingdon, TAYLOR & FRANCIS, 2021, 1562-2975.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.418
• RIV identification code: RIV/00216224:14110/21:00121323
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1080/15622975.2021.1907714
• UT WoS: 000639904700001
• Keywords in English: AMPA/kainate receptor; Nicotine; Methamphetamine; Self-administration; Relapse
• Tags: 14110516, rivok
• Tags: International impact, Reviewed

Abstract

Pharmacological manipulations of glutamatergic ionotropic receptors have been suggested as a promising target for addiction treatment. Antagonists of AMPA/kainate receptors were shown to reduce alcohol intake or alcohol-seeking in various animal models. In this study, we evaluated the effect of NBQX, an AMPA/kainate receptor antagonist, on methamphetamine (METH) and nicotine self-administration in rats.

Links

• MUNI/A/1249/2020, interní kód MU: Name: Základní výzkum v oblasti farmakokinetiky, neurobiologie závislostí a aplikovaný výzkum v oblasti personalizované farmakoterapie v onkologii (Acronym: SV_Farmakologie2021)

Investor: Masaryk University

• MUNI/A/1292/2019, interní kód MU: Name: Preklinický a klinický výzkum studentů v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii

Investor: Masaryk University, Category A