Tooth agenesis: What do we know and is there a connection to cancer?

BONCZEK, Ondrej, Premysl KREJCI, Lydie IZAKOVIČOVÁ HOLLÁ, Pavlína ČERNOCHOVÁ, Igor KISS and Borivoj VOJTESEK. Tooth agenesis: What do we know and is there a connection to cancer? Clinical Genetics. Hoboken: Wiley, 2021, vol. 99, No 4, p. 493-502. ISSN 0009-9163. Available from: https://dx.doi.org/10.1111/cge.13892.

Basic information

• Original name: Tooth agenesis: What do we know and is there a connection to cancer?
• Authors: BONCZEK, Ondrej (203 Czech Republic, guarantor), Premysl KREJCI (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, belonging to the institution), Pavlína ČERNOCHOVÁ (203 Czech Republic, belonging to the institution), Igor KISS (203 Czech Republic) and Borivoj VOJTESEK (203 Czech Republic).
• Edition: Clinical Genetics, Hoboken, Wiley, 2021, 0009-9163.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30101 Human genetics
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.296
• RIV identification code: RIV/00216224:14110/21:00121356
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1111/cge.13892
• UT WoS: 000618548500001
• Keywords in English: cancer; genetic variants; hypodontia; odontogenesis; oligodontia; predictive marker; WNT pathway
• Tags: 14110130, rivok
• Tags: International impact, Reviewed

Abstract

Like all developmental processes, odontogenesis is highly complex and dynamically regulated, with hundreds of genes co-expressed in reciprocal networks. Tooth agenesis (missing one or more/all teeth) is a common human craniofacial anomaly and may be caused by genetic variations and/or environmental factors. Variants in PAX9, MSX1, AXIN2, EDA, EDAR, and WNT10A genes are associated with tooth agenesis. Currently, variants in ATF1, DUSP10, CASC8, IRF6, KDF1, GREM2, LTBP3, and components and regulators of WNT signaling WNT10B, LRP6, DKK, and KREMEN1 are at the forefront of interest. Due to the interconnectedness of the signaling pathways of carcinogenesis and odontogenesis, tooth agenesis could be a suitable marker for early detection of cancer predisposition. Variants in genes associated with tooth agenesis could serve as prognostic or therapeutic targets in cancer. This review aims to summarize existing knowledge of development and clinical genetics of teeth. Concurrently, the review proposes possible approaches for future research in this area, with particular attention to roles in monitoring, early diagnosis and therapy of tumors associated with defective tooth development.