Epigenetic Regulation of MicroRNA Clusters and Families during
Tumor Development

J 2021

Epigenetic Regulation of MicroRNA Clusters and Families during Tumor Development

GREGOROVÁ, Jana, Petra VYCHYTILOVÁ and Sabina ŠEVČÍKOVÁ

Basic information

Original name

Epigenetic Regulation of MicroRNA Clusters and Families during Tumor Development

Authors

GREGOROVÁ, Jana (203 Czech Republic, belonging to the institution), Petra VYCHYTILOVÁ (203 Czech Republic, belonging to the institution) and Sabina ŠEVČÍKOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Cancers, Basel, MDPI, 2021, 2072-6694

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.575

RIV identification code

RIV/00216224:14110/21:00121359

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/cancers13061333

UT WoS

000634331300001

Keywords in English

microRNA clusters; microRNA families; epigenetics; tumor development; DNA methylation; histone modifications; epigenetic therapy

Abstract

V originále

MicroRNAs are small non-coding single-stranded RNA molecules regulating gene expression on a post-transcriptional level based on the seed sequence similarity. They are frequently clustered; thus, they are either simultaneously transcribed into a single polycistronic transcript or they may be transcribed independently. Importantly, microRNA families that contain the same seed region and thus target related signaling proteins, may be localized in one or more clusters, which are in a close relationship. MicroRNAs are involved in basic physiological processes, and their deregulation is associated with the origin of various pathologies, including solid tumors or hematologic malignancies. Recently, the interplay between the expression of microRNA clusters and families and epigenetic machinery was described, indicating aberrant DNA methylation or histone modifications as major mechanisms responsible for microRNA deregulation during cancerogenesis. In this review, the most studied microRNA clusters and families affected by hyper- or hypomethylation as well as by histone modifications are presented with the focus on particular mechanisms. Finally, the diagnostic and prognostic potential of microRNA clusters and families is discussed together with technologies currently used for epigenetic-based cancer therapies.

Citovat

GREGOROVÁ, Jana, Petra VYCHYTILOVÁ and Sabina ŠEVČÍKOVÁ. Epigenetic Regulation of MicroRNA Clusters and Families during Tumor Development. Cancers. Basel: MDPI, 2021, vol. 13, No 6, p. 1-45. ISSN 2072-6694. Available from: https://dx.doi.org/10.3390/cancers13061333.

@article{1758058,
   author = {Gregorová, Jana and Vychytilová, Petra and Ševčíková, Sabina},
   article_location = {Basel},
   article_number = {6},
   doi = {http://dx.doi.org/10.3390/cancers13061333},
   keywords = {microRNA clusters; microRNA families; epigenetics; tumor development; DNA methylation; histone modifications; epigenetic therapy},
   language = {eng},
   issn = {2072-6694},
   journal = {Cancers},
   title = {Epigenetic Regulation of MicroRNA Clusters and Families during Tumor Development},
   url = {https://www.mdpi.com/2072-6694/13/6/1333},
   volume = {13},
   year = {2021}
}

TY  - JOUR
ID  - 1758058
AU  - Gregorová, Jana - Vychytilová, Petra - Ševčíková, Sabina
PY  - 2021
TI  - Epigenetic Regulation of MicroRNA Clusters and Families during Tumor Development
JF  - Cancers
VL  - 13
IS  - 6
SP  - 1-45
EP  - 1-45
PB  - MDPI
SN  - 20726694
KW  - microRNA clusters
KW  - microRNA families
KW  - epigenetics
KW  - tumor development
KW  - DNA methylation
KW  - histone modifications
KW  - epigenetic therapy
UR  - https://www.mdpi.com/2072-6694/13/6/1333
N2  - MicroRNAs are small non-coding single-stranded RNA molecules regulating gene expression on a post-transcriptional level based on the seed sequence similarity. They are frequently clustered; thus, they are either simultaneously transcribed into a single polycistronic transcript or they may be transcribed independently. Importantly, microRNA families that contain the same seed region and thus target related signaling proteins, may be localized in one or more clusters, which are in a close relationship. MicroRNAs are involved in basic physiological processes, and their deregulation is associated with the origin of various pathologies, including solid tumors or hematologic malignancies. Recently, the interplay between the expression of microRNA clusters and families and epigenetic machinery was described, indicating aberrant DNA methylation or histone modifications as major mechanisms responsible for microRNA deregulation during cancerogenesis. In this review, the most studied microRNA clusters and families affected by hyper- or hypomethylation as well as by histone modifications are presented with the focus on particular mechanisms. Finally, the diagnostic and prognostic potential of microRNA clusters and families is discussed together with technologies currently used for epigenetic-based cancer therapies.
ER  -

GREGOROVÁ, Jana, Petra VYCHYTILOVÁ and Sabina ŠEVČÍKOVÁ. Epigenetic Regulation of MicroRNA Clusters and Families during Tumor Development. \textit{Cancers}. Basel: MDPI, 2021, vol.~13, No~6, p.~1-45. ISSN~2072-6694. Available from: https://dx.doi.org/10.3390/cancers13061333.

Detailed Information on Publication Record