Effects of low-dose alcohol exposure in adolescence on
subsequent alcohol drinking in adulthood in a rat model of
depression

J 2021

Effects of low-dose alcohol exposure in adolescence on subsequent alcohol drinking in adulthood in a rat model of depression

ŠIŠKA, Filip, Petra AMCHOVÁ, Daniela KURUCZOVÁ, Yousef TIZABI, Jana RUDÁ et. al.

Basic information

Original name

Effects of low-dose alcohol exposure in adolescence on subsequent alcohol drinking in adulthood in a rat model of depression

Name in Czech

Vliv expozice nízkou dávkou alkoholu v adolescenci na pití alkoholu v dospělosti v potkaním modelu deprese

Authors

ŠIŠKA, Filip (703 Slovakia, belonging to the institution), Petra AMCHOVÁ (203 Czech Republic, belonging to the institution), Daniela KURUCZOVÁ (703 Slovakia, belonging to the institution), Yousef TIZABI (840 United States of America) and Jana RUDÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

The World Journal of Biological Psychiatry, Oxon, TAYLOR & FRANCIS, 2021, 1562-2975

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.418

RIV identification code

RIV/00216224:14110/21:00121364

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1080/15622975.2021.1907717

UT WoS

000643887600001

Keywords in English

Alcohol use disorder; AMPA/kainate receptor; Depression; NBQX; Olfactory bulbectomy; Rats

Abstract

V originále

Adolescence drinking and subsequent development of alcohol use disorder (AUD) is a worldwide health concern. In particular, mood dysregulation or early alcohol exposure can be the cause of heavy drinking in some individuals or a consequence of heavy drinking in others. This study investigated the effects of voluntary alcohol intake during adolescence, i.e. continuous 10% alcohol access between postnatal days (PND) 29 to 43 and olfactory bulbectomy (OBX) model of depression (performed on PND 59) on alcohol drinking in Wistar rats during adulthood (PND 80-120, intermittent 20% alcohol access). In addition, the effect of NBQX, an AMPA/kainate receptor antagonist (5 mg/kg, IP) on spontaneous alcohol consumption was examined.

Links

MUNI/A/1249/2020, interní kód MU

Name: Základní výzkum v oblasti farmakokinetiky, neurobiologie závislostí a aplikovaný výzkum v oblasti personalizované farmakoterapie v onkologii (Acronym: SV_Farmakologie2021)

Investor: Masaryk University

MUNI/A/1292/2019, interní kód MU

Name: Preklinický a klinický výzkum studentů v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii

Investor: Masaryk University, Category A

MUNI/A/1615/2020, interní kód MU

Name: Matematické a statistické modelování 5 (Acronym: MaStaMo5)

Investor: Masaryk University

Citovat

ŠIŠKA, Filip, Petra AMCHOVÁ, Daniela KURUCZOVÁ, Yousef TIZABI and Jana RUDÁ. Effects of low-dose alcohol exposure in adolescence on subsequent alcohol drinking in adulthood in a rat model of depression. The World Journal of Biological Psychiatry. Oxon: TAYLOR & FRANCIS, 2021, vol. 22, No 10, p. 757-769. ISSN 1562-2975. Available from: https://dx.doi.org/10.1080/15622975.2021.1907717.

@article{1758064,
   author = {Šiška, Filip and Amchová, Petra and Kuruczová, Daniela and Tizabi, Yousef and Rudá, Jana},
   article_location = {Oxon},
   article_number = {10},
   doi = {http://dx.doi.org/10.1080/15622975.2021.1907717},
   keywords = {Alcohol use disorder; AMPA/kainate receptor; Depression; NBQX; Olfactory bulbectomy; Rats},
   language = {eng},
   issn = {1562-2975},
   journal = {The World Journal of Biological Psychiatry},
   title = {Effects of low-dose alcohol exposure in adolescence on subsequent alcohol drinking in adulthood in a rat model of depression},
   url = {https://www.tandfonline.com/doi/full/10.1080/15622975.2021.1907717},
   volume = {22},
   year = {2021}
}

TY  - JOUR
ID  - 1758064
AU  - Šiška, Filip - Amchová, Petra - Kuruczová, Daniela - Tizabi, Yousef - Rudá, Jana
PY  - 2021
TI  - Effects of low-dose alcohol exposure in adolescence on subsequent alcohol drinking in adulthood in a rat model of depression
JF  - The World Journal of Biological Psychiatry
VL  - 22
IS  - 10
SP  - 757-769
EP  - 757-769
PB  - TAYLOR & FRANCIS
SN  - 15622975
KW  - Alcohol use disorder
KW  - AMPA/kainate receptor
KW  - Depression
KW  - NBQX
KW  - Olfactory bulbectomy
KW  - Rats
UR  - https://www.tandfonline.com/doi/full/10.1080/15622975.2021.1907717
N2  - Adolescence drinking and subsequent development of alcohol use disorder (AUD) is a worldwide health concern. In particular, mood dysregulation or early alcohol exposure can be the cause of heavy drinking in some individuals or a consequence of heavy drinking in others. This study investigated the effects of voluntary alcohol intake during adolescence, i.e. continuous 10% alcohol access between postnatal days (PND) 29 to 43 and olfactory bulbectomy (OBX) model of depression (performed on PND 59) on alcohol drinking in Wistar rats during adulthood (PND 80-120, intermittent 20% alcohol access). In addition, the effect of NBQX, an AMPA/kainate receptor antagonist (5 mg/kg, IP) on spontaneous alcohol consumption was examined.
ER  -

ŠIŠKA, Filip, Petra AMCHOVÁ, Daniela KURUCZOVÁ, Yousef TIZABI and Jana RUDÁ. Effects of low-dose alcohol exposure in adolescence on subsequent alcohol drinking in adulthood in a rat model of depression. \textit{The World Journal of Biological Psychiatry}. Oxon: TAYLOR \&{} FRANCIS, 2021, vol.~22, No~10, p.~757-769. ISSN~1562-2975. Available from: https://dx.doi.org/10.1080/15622975.2021.1907717.

Detailed Information on Publication Record