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@article{1758096,
author = {Hansen, C. S. and Jorgensen, M. E. and Malík, Marek and Witte, D. R. and Brunner, E. J. and Tabak, A. G. and Kivimaki, M. and Vistisen, D.},
article_location = {ALEXANDRIA},
article_number = {4},
doi = {http://dx.doi.org/10.2337/dc20-2490},
keywords = {Heart Rate; Cardiovascular Disease; Dysglycemia},
language = {eng},
issn = {0149-5992},
journal = {DIABETES CARE},
title = {Heart Rate and Heart Rate Variability Changes Are Not Related to Future Cardiovascular Disease and Death in People With and Without Dysglycemia: A Downfall of Risk Markers? The Whitehall II Cohort Study},
url = {https://care.diabetesjournals.org/content/diacare/44/4/1012.full.pdf},
volume = {44},
year = {2021}
}
TY - JOUR
ID - 1758096
AU - Hansen, C. S. - Jorgensen, M. E. - Malík, Marek - Witte, D. R. - Brunner, E. J. - Tabak, A. G. - Kivimaki, M. - Vistisen, D.
PY - 2021
TI - Heart Rate and Heart Rate Variability Changes Are Not Related to Future Cardiovascular Disease and Death in People With and Without Dysglycemia: A Downfall of Risk Markers? The Whitehall II Cohort Study
JF - DIABETES CARE
VL - 44
IS - 4
SP - 1012-1019
EP - 1012-1019
PB - AMER DIABETES ASSOC
SN - 01495992
KW - Heart Rate
KW - Cardiovascular Disease
KW - Dysglycemia
UR - https://care.diabetesjournals.org/content/diacare/44/4/1012.full.pdf
N2 - OBJECTIVE Higher resting heart rate (rHR) and lower heart rate variability (HRV) are associated with increased risk of cardiovascular disease (CVD) and all-cause mortality in people with and without diabetes. It is unknown whether temporal changes in rHR and HRV may contribute to this risk. We investigated associations between 5-year changes in rHR and HRV and risk of future CVD and death, taking into account participants' baseline glycemic state. RESEARCH DESIGN AND METHODS In this prospective, population-based cohort study we investigated 4,611 CVD-free civil servants (mean [SD] age, 60 [5.9] years; 70% men). We measured rHR and/or six indices of HRV. Associations of 5-year change in 5-min rHR and HRV with fatal and nonfatal CVD and all-cause mortality or the composite of the two were assessed, with adjustments made for relevant confounders. Effect modification by glycemic state was tested. RESULTS At baseline, 63% of participants were normoglycemic, 29% had prediabetes, and 8% had diabetes. During a median (interquartile range) follow-up of 11.9 (11.4; 12.3) years, 298 participants (6.5%) experienced a CVD event and 279 (6.1%) died of non-CVD-related causes. We found no association between 5-year changes in rHR and HRV and future events. Only baseline rHR was associated with all-cause mortality. A 10 bpm-higher baseline HR level was associated with an 11.4% higher rate of all-cause mortality (95% CI 1.0-22.9%; P = 0.032). Glycemic state did not modify associations. CONCLUSIONS Changes in rHR and HRV and possibly also baseline values of these measures are not associated with future CVD or death in people with or without dysglycemia.
ER -
HANSEN, C. S., M. E. JORGENSEN, Marek MALÍK, D. R. WITTE, E. J. BRUNNER, A. G. TABAK, M. KIVIMAKI and D. VISTISEN. Heart Rate and Heart Rate Variability Changes Are Not Related to Future Cardiovascular Disease and Death in People With and Without Dysglycemia: A Downfall of Risk Markers? The Whitehall II Cohort Study. \textit{DIABETES CARE}. ALEXANDRIA: AMER DIABETES ASSOC, 2021, vol.~44, No~4, p.~1012-1019. ISSN~0149-5992. Available from: https://dx.doi.org/10.2337/dc20-2490.
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