Oxidized polysaccharides for anticancer-drug delivery: What is
the role of structure?

J 2021

Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?

MUNSTER, Lukas, Michaela FOJTŮ, Zdenka CAPAKOVA, Monika MUCHOVA, Lenka MUSILOVA et. al.

Basic information

Original name

Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?

Authors

MUNSTER, Lukas (203 Czech Republic), Michaela FOJTŮ (203 Czech Republic, belonging to the institution), Zdenka CAPAKOVA (203 Czech Republic), Monika MUCHOVA (203 Czech Republic), Lenka MUSILOVA (203 Czech Republic), Tomáš VACULOVIČ (203 Czech Republic, belonging to the institution), Jan BALVAN (203 Czech Republic, belonging to the institution), Ivo KURITKA (203 Czech Republic), Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution) and Jan VICHA (203 Czech Republic)

Edition

Carbohydrate Polymers, Oxford, ELSEVIER SCI LTD, 2021, 0144-8617

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10404 Polymer science

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 10.723

RIV identification code

RIV/00216224:14110/21:00121369

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.carbpol.2020.117562

UT WoS

000617787500009

Keywords in English

Drug delivery; Cellulose; Dextran; Dextrin; Sodium hyaluronate; Selective oxidation

Abstract

V originále

Study provides an in-depth analysis of the structure-function relationship of polysaccharide anticancer drug carriers and points out benefits and potential drawbacks of differences in polysaccharide glycosidic bonding, branching and drug binding mode of the carriers. Cellulose, dextrin, dextran and hyaluronic acid have been regioselectively oxidized to respective dicarboxylated derivatives, allowing them to directly conjugate cisplatin, while preserving their major structural features intact. The structure of source polysaccharide has crucial impact on conjugation effectiveness, carrier capacity, drug release rates, in vitro cytotoxicity and cellular uptake. For example, while branched structure of dextrin-based carrier partially counter the undesirable initial burst release, it also attenuates the cellular uptake and the cytotoxicity of carried drug. Linear polysaccharides containing beta-(1 -> 4) glycosidic bonds and oxidized at C2 and C3 (cellulose and hyaluronate) have the best overall combination of structural features for improved drug delivery applications including potentiation of the cisplatin efficacy towards malignances.

Links

LM2018127, research and development project

Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)

Investor: Ministry of Education, Youth and Sports of the CR

LM2018140, research and development project

Name: e-Infrastruktura CZ (Acronym: e-INFRA CZ)

Investor: Ministry of Education, Youth and Sports of the CR

ROZV/28/LF17/2020, interní kód MU

Name: Magnetoboti pro fototermální a magnetotermální terapii nádorových onemocnění

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

MUNSTER, Lukas, Michaela FOJTŮ, Zdenka CAPAKOVA, Monika MUCHOVA, Lenka MUSILOVA, Tomáš VACULOVIČ, Jan BALVAN, Ivo KURITKA, Michal MASAŘÍK and Jan VICHA. Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure? Carbohydrate Polymers. Oxford: ELSEVIER SCI LTD, 2021, vol. 257, APR 2021, p. 1-12. ISSN 0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2020.117562.

@article{1758099,
   author = {Munster, Lukas and Fojtů, Michaela and Capakova, Zdenka and Muchova, Monika and Musilova, Lenka and Vaculovič, Tomáš and Balvan, Jan and Kuritka, Ivo and Masařík, Michal and Vicha, Jan},
   article_location = {Oxford},
   article_number = {APR 2021},
   doi = {http://dx.doi.org/10.1016/j.carbpol.2020.117562},
   keywords = {Drug delivery; Cellulose; Dextran; Dextrin; Sodium hyaluronate; Selective oxidation},
   language = {eng},
   issn = {0144-8617},
   journal = {Carbohydrate Polymers},
   title = {Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?},
   url = {https://www.sciencedirect.com/science/article/pii/S0144861720317355?via%3Dihub},
   volume = {257},
   year = {2021}
}

TY  - JOUR
ID  - 1758099
AU  - Munster, Lukas - Fojtů, Michaela - Capakova, Zdenka - Muchova, Monika - Musilova, Lenka - Vaculovič, Tomáš - Balvan, Jan - Kuritka, Ivo - Masařík, Michal - Vicha, Jan
PY  - 2021
TI  - Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?
JF  - Carbohydrate Polymers
VL  - 257
IS  - APR 2021
SP  - 1-12
EP  - 1-12
PB  - ELSEVIER SCI LTD
SN  - 01448617
KW  - Drug delivery
KW  - Cellulose
KW  - Dextran
KW  - Dextrin
KW  - Sodium hyaluronate
KW  - Selective oxidation
UR  - https://www.sciencedirect.com/science/article/pii/S0144861720317355?via%3Dihub
N2  - Study provides an in-depth analysis of the structure-function relationship of polysaccharide anticancer drug carriers and points out benefits and potential drawbacks of differences in polysaccharide glycosidic bonding, branching and drug binding mode of the carriers. Cellulose, dextrin, dextran and hyaluronic acid have been regioselectively oxidized to respective dicarboxylated derivatives, allowing them to directly conjugate cisplatin, while preserving their major structural features intact. The structure of source polysaccharide has crucial impact on conjugation effectiveness, carrier capacity, drug release rates, in vitro cytotoxicity and cellular uptake. For example, while branched structure of dextrin-based carrier partially counter the undesirable initial burst release, it also attenuates the cellular uptake and the cytotoxicity of carried drug. Linear polysaccharides containing beta-(1 -> 4) glycosidic bonds and oxidized at C2 and C3 (cellulose and hyaluronate) have the best overall combination of structural features for improved drug delivery applications including potentiation of the cisplatin efficacy towards malignances.
ER  -

MUNSTER, Lukas, Michaela FOJTŮ, Zdenka CAPAKOVA, Monika MUCHOVA, Lenka MUSILOVA, Tomáš VACULOVIČ, Jan BALVAN, Ivo KURITKA, Michal MASAŘÍK and Jan VICHA. Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure? \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2021, vol.~257, APR 2021, p.~1-12. ISSN~0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2020.117562.

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