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@article{1758356,
author = {Jabandžiev, Petr and Kakisaka, Tatsuhiko and Bohošová, Júlia and Pinkasová, Tereza and Kunovský, Lumír and Slabý, Ondřej and Goel, Ajay},
article_location = {Basel},
article_number = {6},
doi = {http://dx.doi.org/10.3390/jcm10061325},
keywords = {pediatrics; inflammatory bowel disease; ulcerative colitis; microrna; primary sclerosing cholangitis},
language = {eng},
issn = {2077-0383},
journal = {Journal of Clinical Medicine},
title = {MicroRNAs in Colon Tissue of Pediatric Ulcerative Pancolitis Patients Allow Detection and Prognostic Stratification},
url = {https://www.mdpi.com/2077-0383/10/6/1325/htm},
volume = {10},
year = {2021}
}
TY - JOUR
ID - 1758356
AU - Jabandžiev, Petr - Kakisaka, Tatsuhiko - Bohošová, Júlia - Pinkasová, Tereza - Kunovský, Lumír - Slabý, Ondřej - Goel, Ajay
PY - 2021
TI - MicroRNAs in Colon Tissue of Pediatric Ulcerative Pancolitis Patients Allow Detection and Prognostic Stratification
JF - Journal of Clinical Medicine
VL - 10
IS - 6
SP - 1-11
EP - 1-11
PB - MDPI
SN - 20770383
KW - pediatrics
KW - inflammatory bowel disease
KW - ulcerative colitis
KW - microrna
KW - primary sclerosing cholangitis
UR - https://www.mdpi.com/2077-0383/10/6/1325/htm
N2 - Prevalence of inflammatory bowel disease has been on the rise in recent years, especially in pediatric populations. This study aimed to provide precise identification and stratification of pediatric patients with diagnosed ulcerative colitis (UC) according to the severity of their condition and the prediction for standard treatment according to the specific expression of candidate miRNAs. We enrolled consecutive, therapeutically naive, pediatric UC patients with confirmed pancolitis. We examined formalin-fixed paraffin-embedded specimens of colonic tissue for the expression of 10 selected candidate miRNAs. We performed receiver operating characteristic curve analysis, using area under the curve and a logistic regression model to evaluate the diagnostic and predictive power of the miRNA panels. Sixty patients were included in the final analysis. As a control group, 18 children without macroscopic and microscopic signs of inflammatory bowel disease were examined. The combination of three candidate miRNAs (let-7i-5p, miR-223-3p and miR-4284) enabled accurate detection of pediatric UC patients and controls. A panel of four candidate miRNAs (miR-375-3p, miR-146a-5p, miR-223-3p and miR-200b-3p) was associated with severity of UC in pediatric patients and a combination of three miRNAs (miR-21-5p, miR-192-5p and miR-194-5p) was associated with early relapse of the disease. Nine patients out of the total were diagnosed with primary sclerosing cholangitis (PSC) simultaneously with ulcerative colitis. A panel of 6 candidate miRNAs (miR-142-3p, miR-146a-5p, miR-223-3p, let-7i-5p, miR-192-5p and miR-194-5p) identified those patients with PSC. Specific combinations of miRNAs are promising tools for potential use in precise disease identification and severity and prognostic stratification in pediatric patients with ulcerative pancolitis.
ER -
JABANDŽIEV, Petr, Tatsuhiko KAKISAKA, Júlia BOHOŠOVÁ, Tereza PINKASOVÁ, Lumír KUNOVSKÝ, Ondřej SLABÝ and Ajay GOEL. MicroRNAs in Colon Tissue of Pediatric Ulcerative Pancolitis Patients Allow Detection and Prognostic Stratification. \textit{Journal of Clinical Medicine}. Basel: MDPI, 2021, vol.~10, No~6, p.~1-11. ISSN~2077-0383. Available from: https://dx.doi.org/10.3390/jcm10061325.
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