On the relation of white matter brain abnormalities and the
asociality symptoms in schizophrenia outpatients - a DTI study

J 2021

On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients - a DTI study

ADAMCZYK, Przemysław, Olga PŁONKA, Dawid KRUK, Martin JÁNI, Piotr BŁĄDZIŃSKI et. al.

Basic information

Original name

On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients - a DTI study

Authors

ADAMCZYK, Przemysław (616 Poland, guarantor), Olga PŁONKA (616 Poland), Dawid KRUK (616 Poland), Martin JÁNI (703 Slovakia, belonging to the institution), Piotr BŁĄDZIŃSKI (616 Poland), Aneta KALISZ (616 Poland), Stynke CASTELEIN (528 Netherlands), Andrzej CECHNICKI (616 Poland) and Miroslaw WYCZESANY (616 Poland)

Edition

Acta Neurobiologiae Experimentalis, Warsaw, NENCKI INST EXPERIMENTAL BIOLOGY, 2021, 0065-1400

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.269

RIV identification code

RIV/00216224:14110/21:00121375

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.21307/ane-2021-009

UT WoS

000635355400008

Keywords in English

schizophrenia; diffusion tensor imaging; white matter; negative symptoms; psychopathology

Abstract

V originále

Recent MRI studies have shown that abnormal functional connections in schizophrenia coexist with subtle changes in the structure of axons in the brain. However, there is a discrepancy in the literature concerning the relationship between white matter abnormalities and the occurrence of negative psychopathological symptoms. In the present study, we investigate the relationship between the altered white matter structure and specific psychopathology symptoms, i.e., subscales of Positive and Negative Syndrome Scale (PANSS) and Brief Negative Symptoms Scale (BNSS) in a sample of schizophrenia outpatients. For investigation on white matter abnormalities in schizophrenia, the diffusion tensor imaging analysis of between-group differences in main diffusion parameters by tract-based spatial statistics was conducted on schizophrenia outpatients and healthy controls. Hence, the correlation of PANSS and BNSS psychopathology subscales in the clinical group with fractional anisotropy was analyzed in the 17 selected cortical regions of interest. Presented between-group results revealed widespread loss of white matter integrity located across the brain in schizophrenia outpatients. Results on the white matter relationship with psychopathology revealed the negative correlation between fractional anisotropy in the left orbital prefrontal cortex, right Heschl's gyrus, bilateral precuneus and posterior cingulate cortex and the severity of asociality, as assessed with the BNSS. In conclusion, the presented study confirms the previous evidence on the widespread white matter abnormalities in schizophrenia outpatients and indicates the existence of the subtle but specific association between fractional anisotropy in the fronto-temporo-parietal regions with the asociality.

Citovat

ADAMCZYK, Przemysław, Olga PŁONKA, Dawid KRUK, Martin JÁNI, Piotr BŁĄDZIŃSKI, Aneta KALISZ, Stynke CASTELEIN, Andrzej CECHNICKI and Miroslaw WYCZESANY. On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients - a DTI study. Acta Neurobiologiae Experimentalis. Warsaw: NENCKI INST EXPERIMENTAL BIOLOGY, 2021, vol. 81, No 1, p. 80-95. ISSN 0065-1400. Available from: https://dx.doi.org/10.21307/ane-2021-009.

@article{1758359,
   author = {Adamczyk, Przemysław and Płonka, Olga and Kruk, Dawid and Jáni, Martin and Błądziński, Piotr and Kalisz, Aneta and Castelein, Stynke and Cechnicki, Andrzej and Wyczesany, Miroslaw},
   article_location = {Warsaw},
   article_number = {1},
   doi = {http://dx.doi.org/10.21307/ane-2021-009},
   keywords = {schizophrenia; diffusion tensor imaging; white matter; negative symptoms; psychopathology},
   language = {eng},
   issn = {0065-1400},
   journal = {Acta Neurobiologiae Experimentalis},
   title = {On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients - a DTI study},
   url = {https://www.exeley.com/exeley/journals/acta_neurobiologiae_experimentalis/81/i_current/pdf/10.21307_ane-2021-009.pdf},
   volume = {81},
   year = {2021}
}

TY  - JOUR
ID  - 1758359
AU  - Adamczyk, Przemysław - Płonka, Olga - Kruk, Dawid - Jáni, Martin - Błądziński, Piotr - Kalisz, Aneta - Castelein, Stynke - Cechnicki, Andrzej - Wyczesany, Miroslaw
PY  - 2021
TI  - On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients - a DTI study
JF  - Acta Neurobiologiae Experimentalis
VL  - 81
IS  - 1
SP  - 80-95
EP  - 80-95
PB  - NENCKI INST EXPERIMENTAL BIOLOGY
SN  - 00651400
KW  - schizophrenia
KW  - diffusion tensor imaging
KW  - white matter
KW  - negative symptoms
KW  - psychopathology
UR  - https://www.exeley.com/exeley/journals/acta_neurobiologiae_experimentalis/81/i_current/pdf/10.21307_ane-2021-009.pdf
N2  - Recent MRI studies have shown that abnormal functional connections in schizophrenia coexist with subtle changes in the structure of axons in the brain. However, there is a discrepancy in the literature concerning the relationship between white matter abnormalities and the occurrence of negative psychopathological symptoms. In the present study, we investigate the relationship between the altered white matter structure and specific psychopathology symptoms, i.e., subscales of Positive and Negative Syndrome Scale (PANSS) and Brief Negative Symptoms Scale (BNSS) in a sample of schizophrenia outpatients. For investigation on white matter abnormalities in schizophrenia, the diffusion tensor imaging analysis of between-group differences in main diffusion parameters by tract-based spatial statistics was conducted on schizophrenia outpatients and healthy controls. Hence, the correlation of PANSS and BNSS psychopathology subscales in the clinical group with fractional anisotropy was analyzed in the 17 selected cortical regions of interest. Presented between-group results revealed widespread loss of white matter integrity located across the brain in schizophrenia outpatients. Results on the white matter relationship with psychopathology revealed the negative correlation between fractional anisotropy in the left orbital prefrontal cortex, right Heschl's gyrus, bilateral precuneus and posterior cingulate cortex and the severity of asociality, as assessed with the BNSS. In conclusion, the presented study confirms the previous evidence on the widespread white matter abnormalities in schizophrenia outpatients and indicates the existence of the subtle but specific association between fractional anisotropy in the fronto-temporo-parietal regions with the asociality.
ER  -

ADAMCZYK, Przemysław, Olga PŁONKA, Dawid KRUK, Martin JÁNI, Piotr BŁĄDZI$\backslash$'NSKI, Aneta KALISZ, Stynke CASTELEIN, Andrzej CECHNICKI and Miroslaw WYCZESANY. On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients - a DTI study. \textit{Acta Neurobiologiae Experimentalis}. Warsaw: NENCKI INST EXPERIMENTAL BIOLOGY, 2021, vol.~81, No~1, p.~80-95. ISSN~0065-1400. Available from: https://dx.doi.org/10.21307/ane-2021-009.

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