KUCAKOVA, K. and B. DOLENSKY. Molecular structure study of a heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin complex of cholesterol. Steroids. New York: ELSEVIER SCIENCE INC, 2020, vol. 155, MAR, p. 108555-108563. ISSN 0039-128X. Available from: https://dx.doi.org/10.1016/j.steroids.2019.108555.
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Basic information
Original name Molecular structure study of a heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin complex of cholesterol
Authors KUCAKOVA, K. and B. DOLENSKY.
Edition Steroids, New York, ELSEVIER SCIENCE INC, 2020, 0039-128X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10608 Biochemistry and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.668
RIV identification code RIV/00216224:14740/20:00121452
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1016/j.steroids.2019.108555
UT WoS 000517349300010
Keywords in English Cholesterol; Cyclodextrin; Complex; Structure; NMR
Tags ne MU, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 29/4/2021 12:22.
Abstract
Heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin (2) and cholesterol form a water-soluble complex 3. We performed several NMR studies, particularly H-1, C-13, 2D NOESY and DOSY, at various temperatures on 500 and 950 MHz instruments. We discovered that the complex 3 is unstable above 57 degrees C in heavy water, while it is kinetically stable enough to be studied by NMR in detail at 1 degrees C. We demonstrated the formation of a face-to-face 2:1 complex with a binding constant of approximately 2.2 x 10(6) M-2.
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