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@article{1762976,
author = {Husa, Petr and Snopková, Svatava and Zavřelová, Jiřina and Zlámal, Filip and Svačinka, Radek and Husa, Petr},
article_location = {Olomouc},
article_number = {2},
doi = {http://dx.doi.org/10.5507/bp.2021.023},
keywords = {microparticles; microvesicles; chronic hepatitis C; direct-acting antivirotics},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers},
title = {Circulating microparticles in patients with chronic hepatitis C and changes during direct-acting antiviral therapy},
url = {https://biomed.papers.upol.cz/artkey/bio-202102-0005_circulating-microparticles-in-patients-with-chronic-hepatitis-c-and-changes-during-direct-acting-antiviral-ther.php},
volume = {165},
year = {2021}
}
TY - JOUR
ID - 1762976
AU - Husa, Petr - Snopková, Svatava - Zavřelová, Jiřina - Zlámal, Filip - Svačinka, Radek - Husa, Petr
PY - 2021
TI - Circulating microparticles in patients with chronic hepatitis C and changes during direct-acting antiviral therapy
JF - Biomedical Papers
VL - 165
IS - 2
SP - 146-151
EP - 146-151
PB - Univerzita Palackého v Olomouci
SN - 12138118
KW - microparticles
KW - microvesicles
KW - chronic hepatitis C
KW - direct-acting antivirotics
UR - https://biomed.papers.upol.cz/artkey/bio-202102-0005_circulating-microparticles-in-patients-with-chronic-hepatitis-c-and-changes-during-direct-acting-antiviral-ther.php
N2 - Background. Microparticles (MPs) are heterogeneous vesicles derived from membranes of different cells. Between 70 to 90% of MPs detected in blood originate from platelets. The release of MPs is associated with proinflammatory and procoagulant states. Elevated levels of MPs have been found in different diseases. We investigated MPs levels in patients with chronic hepatitis C (CHC) and changes in level during treatment using direct-acting antivirotics (DAA). Patients and Methods. Thirty-six patients with CHC and forty healthy volunteers were included in the study. Concentrations of MPs were determined indirectly by measuring their procoagulant activity in plasma at baseline, end of therapy (EOT), and 12 weeks after EOT when the sustained virological response was assessed (SVR12). Results. All patients achieved SVR12, which was associated with rapid improvement of markers of liver damage and function as well as liver stiffness (P=0.002). MPs levels were significantly higher in CHC patients than in healthy volunteers (P<0.001). No statistically significant decrease was found observed between baseline and SVR12 (P=0.330). Analysis of subpopulations with minimal fibrosis F0-1 (P=0.647), advanced fibrosis F2-4 (P=0.370), women(P=0.847), men (P=0.164) and genotype 1 (P=0.077) showed no significant changes during the follow-up period. Conclusions. MPs levels are higher in CHC patients and remain elevated shortly after achieving SVR. Higher concentrations of MPs in plasma are probably caused by a chronic uncontrolled exaggerated inflammatory response caused by CHC. Longer observation would probably confirm the significance of MPs levels decrease because normalization of liver function, inflammation, and structure after SVR requires more than 12 weeks.
ER -
HUSA, Petr, Svatava SNOPKOVÁ, Jiřina ZAVŘELOVÁ, Filip ZLÁMAL, Radek SVAČINKA and Petr HUSA. Circulating microparticles in patients with chronic hepatitis C and changes during direct-acting antiviral therapy. \textit{Biomedical Papers}. Olomouc: Univerzita Palackého v Olomouci, 2021, vol.~165, No~2, p.~146-151. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2021.023.
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