ZAPARDIEL, I., Roman KOCIAN, C. KOHLER, Jaroslav KLAT, Anna GERMANOVA, A. JACOB, Sylva BAJSOVA, G. BOHMER, L. LAY, B. GIL-IBANEZ, Pavel HAVELKA, B. KIPP, G. SZEWCZYK, R. TOTH, J. C. STARINGER, J. DE SANTIAGO, P. J. CORONADO, R. POKA, R. LAKY, M. LUYCKX, M. FASTREZ, Ladislav DUŠEK, A. HERNANDEZ and David CIBULA. Voiding recovery after radical parametrectomy in cervical cancer patients: An international prospective multicentre trial - SENTIX. Gynecologic Oncology. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2021, vol. 160, No 3, p. 729-734. ISSN 0090-8258. Available from: https://dx.doi.org/10.1016/j.ygyno.2020.12.018.
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Basic information
Original name Voiding recovery after radical parametrectomy in cervical cancer patients: An international prospective multicentre trial - SENTIX
Authors ZAPARDIEL, I. (guarantor), Roman KOCIAN (203 Czech Republic), C. KOHLER, Jaroslav KLAT (203 Czech Republic), Anna GERMANOVA (203 Czech Republic), A. JACOB, Sylva BAJSOVA (203 Czech Republic), G. BOHMER, L. LAY, B. GIL-IBANEZ, Pavel HAVELKA (203 Czech Republic), B. KIPP, G. SZEWCZYK, R. TOTH, J. C. STARINGER, J. DE SANTIAGO, P. J. CORONADO, R. POKA, R. LAKY, M. LUYCKX, M. FASTREZ, Ladislav DUŠEK (203 Czech Republic, belonging to the institution), A. HERNANDEZ and David CIBULA (203 Czech Republic).
Edition Gynecologic Oncology, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2021, 0090-8258.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30214 Obstetrics and gynaecology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 5.304
RIV identification code RIV/00216224:14110/21:00121473
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.ygyno.2020.12.018
UT WoS 000620805400014
Keywords in English Radical hysterectomy; Parametrectomy; Cervical cancer; Voiding recovery; Nerve-sparing techniques
Tags 14119612, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 26/4/2021 14:06.
Abstract
OBJECTIVE: Voiding dysfunctions represent a leading morbidity after radical hysterectomy performed in patients with early-stage cervical cancer. The aim of this study was to perform ad hoc analysis of factors influencing voiding recovery in SENTIX (SENTinel lymph node biopsy in cervIX cancer) trial. METHODS: The SENTIX trial (47 sites, 18 countries) is a prospective study on sentinel lymph node biopsy without pelvic lymphadenectomy in patients with early-stage cervical cancer. Overall, the data of 300 patients were analysed. Voiding recovery was defined as the number of days from surgery to bladder catheter/epicystostomy removal or to post-voiding urine residuum <= 50 mL. RESULTS: The median voiding recovery time was three days (5th-95th percentile: 0-21): 235 (78.3%) patients recovered in <7 days and 293 (97.7%) in 30 days. Only seven (2.3%) patients recovered after 0.001) significantly influenced voiding recovery 7 days post-surgery. Type-B parametrectomy was associated with a higher risk of delayed voiding recovery than type-C1 (OR = 4.69; p = 0.023 vs. OR = 3.62; p = 0.052, respectively), followed by type-C2 (OR = 5.84; p = 0.011). Both previous pregnancy and type C2 parametrectomy indepen-dently prolonged time to voiding recovery by two days. CONCLUSIONS: Time to voiding recovery is significantly related to previous pregnancy and type of parametrectomy but it is not influenced by surgical approach (open vs minimally invasive), age, or BMI. Type B parametrectomy, without direct visualisation of nerves, was associated with longer recovery than nerve-sparing type C1. Importantly, voiding dysfunctions after radical surgery are temporary, and the majority of the patients recover in less than 30 days, including patients after C2 parametrectomy. (C) 2020 Elsevier Inc. All rights reserved.
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